How can we use the endocytosis pathways to design nanoparticle drug-delivery vehicles to target cancer cells over healthy cells?
Targeted drug delivery in cancer typically focuses on maximising the endocytosis of drugs
into the diseased cells. However, there has been less focus on exploiting the differences in …
into the diseased cells. However, there has been less focus on exploiting the differences in …
Targeting drug chemo-resistance in cancer using natural products
Cancer is one of the leading causes of death globally. The development of drug resistance
is the main contributor to cancer-related mortality. Cancer cells exploit multiple mechanisms …
is the main contributor to cancer-related mortality. Cancer cells exploit multiple mechanisms …
Converting peptides into drugs targeting intracellular protein–protein interactions
Highlights•Cyclic peptides are ideal inhibitors of protein–protein interactions (PPIs), due to
low immunogenicity and large surface area.•Peptide libraries are excellent tools to screen …
low immunogenicity and large surface area.•Peptide libraries are excellent tools to screen …
The dual role of macropinocytosis in cancers: promoting growth and inducing methuosis to participate in anticancer therapies as targets
S Song, Y Zhang, T Ding, N Ji, H Zhao - Frontiers in Oncology, 2021 - frontiersin.org
Macropinocytosis is an important mechanism of internalizing extracellular materials and
dissolved molecules in eukaryotic cells. Macropinocytosis has a dual effect on cancer cells …
dissolved molecules in eukaryotic cells. Macropinocytosis has a dual effect on cancer cells …
Approaches and materials for endocytosis-independent intracellular delivery of proteins
N Chen, Y He, M Zang, Y Zhang, H Lu, Q Zhao… - Biomaterials, 2022 - Elsevier
The intracellular delivery of proteins is of great significance. For diseases such as cancer,
heart disease and neurodegenerative diseases, many important pharmacological targets …
heart disease and neurodegenerative diseases, many important pharmacological targets …
Understanding intracellular biology to improve mRNA delivery by lipid nanoparticles
Poor understanding of intracellular delivery and targeting hinders development of nucleic
acid‐based therapeutics transported by nanoparticles. Utilizing a siRNA‐targeting and small …
acid‐based therapeutics transported by nanoparticles. Utilizing a siRNA‐targeting and small …
Liquid droplet formation and facile cytosolic translocation of IgG in the presence of attenuated cationic amphiphilic lytic peptides
Fc region binding peptide conjugated with attenuated cationic amphiphilic lytic peptide L17E
trimer [FcB (L17E) 3] was designed for immunoglobulin G (IgG) delivery into cells. Particle …
trimer [FcB (L17E) 3] was designed for immunoglobulin G (IgG) delivery into cells. Particle …
[HTML][HTML] Advances in peptide-mediated cytosolic delivery of proteins
M Sánchez-Navarro - Advanced Drug Delivery Reviews, 2021 - Elsevier
The number of protein-based drugs is exponentially increasing. However, development of
protein therapeutics against intracellular targets is hampered by the lack of efficient cytosolic …
protein therapeutics against intracellular targets is hampered by the lack of efficient cytosolic …
Finding ways into the cytosol: Peptide-mediated approaches for delivering proteins into cells
Y Kawaguchi, S Futaki - Current Opinion in Chemical Biology, 2024 - Elsevier
The delivery of functional proteins, including antibodies, into cells opens up many
opportunities to regulate cellular events, with significant implications for studies in chemical …
opportunities to regulate cellular events, with significant implications for studies in chemical …
Membrane trafficking and subcellular drug targeting pathways
The movement of micro and macro molecules into and within a cell significantly governs
several of their pharmacokinetic and pharmacodynamic parameters, thus regulating the …
several of their pharmacokinetic and pharmacodynamic parameters, thus regulating the …