Cancer is one of the leading causes of death globally. The development of drug resistance
is the main contributor to cancer-related mortality. Cancer cells exploit multiple mechanisms …

Targeted drug delivery in cancer typically focuses on maximising the endocytosis of drugs
into the diseased cells. However, there has been less focus on exploiting the differences in …

Poor understanding of intracellular delivery and targeting hinders development of nucleic
acid‐based therapeutics transported by nanoparticles. Utilizing a siRNA‐targeting and small …

Therapeutic proteins provided new opportunities for patients and high sales volumes.
However, they are formulated for extracellular targets. The lipophilic barrier of the plasma …

Highlights•Cyclic peptides are ideal inhibitors of protein–protein interactions (PPIs), due to
low immunogenicity and large surface area.•Peptide libraries are excellent tools to screen …

Macropinocytosis is an important mechanism of internalizing extracellular materials and
dissolved molecules in eukaryotic cells. Macropinocytosis has a dual effect on cancer cells …

The intracellular delivery of proteins is of great significance. For diseases such as cancer,
heart disease and neurodegenerative diseases, many important pharmacological targets …

Fc region binding peptide conjugated with attenuated cationic amphiphilic lytic peptide L17E
trimer [FcB (L17E) 3] was designed for immunoglobulin G (IgG) delivery into cells. Particle …

Simple Summary Gene therapy is one of the most promising approaches to treating various
inherited and acquired diseases by delivering genetic constructs into the cells and tissues of …

The number of protein-based drugs is exponentially increasing. However, development of
protein therapeutics against intracellular targets is hampered by the lack of efficient cytosolic …