Cells of all living organisms contain complex signal transduction networks to ensure that a
wide range of physiological properties are properly adapted to the environmental conditions …

Pho85 is a multifunctional cyclin‐dependent kinase (Cdk) in Saccharomyces cerevisiae that
has emerged as an important model for the role of Cdks in both cell cycle control and other …

In budding yeast, the essential functions of Hsp70 chaperones Ssa1–4 are regulated
through expression level, isoform specificity, and cochaperone activity. Suggesting a novel …

Eukaryotic genome encodes numerous WD40 repeat proteins, which generally function as
platforms of protein-protein interactions and are involved in numerous biological process …

Protein phosphorylation plays a central role in cellular regulation. Recent proteomics
strategies for identifying phosphopeptides have been developed using the model organism …

The F-box domain, so called after a conserved domain found in human cyclin F (5), was
described in 1996 (6) after first being denoted a conserved N-terminal domain found in a …

Pho85 is a multifunctional CDK that signals to the cell when environmental conditions are
favorable. It has been connected to cell cycle control, mainly in Start where it promotes the …

The DNA damage checkpoint is a stress response pathway detecting pathological structures
of nuclear DNA and inducing appropriate responses. These responses include cell cycle …

As a major intracellular degradation pathway, autophagy is tightly regulated to prevent
cellular dysfunction in all eukaryotic cells. The rapamycin-sensitive Tor kinase complex 1 is …

Upon environmental changes, proliferating cells delay cell cycle to prevent further damage
accumulation. Yeast Cip1 is a Cdk1 and Cln2-associated protein. However, the function and …