Bone is a dynamic tissue constantly responding to environmental changes such as
nutritional and mechanical stress. Bone homeostasis in adult life is maintained through bone …

Abstract microRNAs (miRNAs) are important modulators of development. Owing to their
ability to simultaneously silence hundreds of target genes, they have key roles in large-scale …

Emerging evidence indicates that microRNAs (miRNAs) have important roles in regulating
osteogenic differentiation and bone formation. Thus far, no study has established the …

Lineage progression in osteoblasts and chondrocytes is stringently controlled by the cell-
fate–determining transcription factor Runx2. In this study, we directly addressed whether …

Recent evidence suggests that physical exercise (EX) promotes skeletal development.
However, the impact of EX on the progression of bone loss and deterioration of mechanical …

Cartilage and bone are severely affected by glucocorticoids (GCs), steroid hormones that
are frequently used to treat inflammatory diseases. Major complications associated with long …

MicroRNAs (miRNAs) repress cellular protein levels to provide a sophisticated parameter of
gene regulation that coordinates a broad spectrum of biological processes. Bone …

Abstract Purpose of Review Osteoarthritis (OA) is a subset of joint disorders resulting in
degeneration of synovial joints. This leads to pain, disability and loss of independence …

Induced osteogenesis includes a program of microRNAs (miRs) to repress the translation of
genes that act as inhibitors of bone formation. How expression of bone-related miRs is …

MicroRNAs (miRNAs) negatively and post-transcriptionally regulate expression of multiple
target genes to support anabolic pathways for bone formation. Here, we show that miR-218 …