The main molecular mechanisms underlying methamphetamine-induced neurotoxicity and implications for pharmacological treatment

X Yang, Y Wang, Q Li, Y Zhong, L Chen… - Frontiers in molecular …, 2018‏ - frontiersin.org
Methamphetamine (METH) is a popular new-type psychostimulant drug with complicated
neurotoxicity. In spite of mounting evidence on METH-induced damage of neural cell, the …

Effects of drugs of abuse on the blood-brain barrier: a brief overview

E Pimentel, K Sivalingam, M Doke… - Frontiers in …, 2020‏ - frontiersin.org
The use of psychostimulants and alcohol disrupts blood-brain barrier (BBB) integrity,
resulting in alterations to cellular function, and contributes to neurotoxicity. The BBB is the …

Circular RNA HIPK2 regulates astrocyte activation via cooperation of autophagy and ER stress by targeting MIR124–2HG

R Huang, Y Zhang, B Han, Y Bai, R Zhou, G Gan… - Autophagy, 2017‏ - Taylor & Francis
Circular RNAs are a subclass of noncoding RNAs in mammalian cells; however, whether
these RNAs are involved in the regulation of astrocyte activation is largely unknown. Here …

Methamphetamine: Effects on the brain, gut and immune system

MD Prakash, K Tangalakis, J Antonipillai… - Pharmacological …, 2017‏ - Elsevier
Methamphetamine (METH) is a powerful central nervous system stimulant which elevates
mood, alertness, energy levels and concentration in the short-term. However, chronic use …

Neuroinflammation in addiction: A review of neuroimaging studies and potential immunotherapies

M Kohno, J Link, LE Dennis, H McCready… - Pharmacology …, 2019‏ - Elsevier
Addiction is a worldwide public health problem and this article reviews scientific advances in
identifying the role of neuroinflammation in the genesis, maintenance, and treatment of …

Microglia in neuroimmunopharmacology and drug addiction

H Li, LR Watkins, X Wang - Molecular Psychiatry, 2024‏ - nature.com
Drug addiction is a chronic and debilitating disease that is considered a global health
problem. Various cell types in the brain are involved in the progression of drug addiction …

Mechanisms of action and persistent neuroplasticity by drugs of abuse

ER Korpi, B den Hollander, U Farooq… - Pharmacological …, 2015‏ - Elsevier
Adaptation of the nervous system to different chemical and physiologic conditions is
important for the homeostasis of brain processes and for learning and remembering …

Asiatic acid attenuates methamphetamine-induced neuroinflammation and neurotoxicity through blocking of NF-kB/STAT3/ERK and mitochondria-mediated apoptosis …

JH Park, YH Seo, JH Jang, CH Jeong, S Lee… - Journal of …, 2017‏ - Springer
Background Methamphetamine (METH) is a commonly abused drug that may result in
neurotoxic effects. Recent studies have suggested that involvement of neuroinflammatory …

Glioblastoma stem cells are regulated by interleukin-8 signaling in a tumoral perivascular niche

DW Infanger, YJ Cho, BS Lopez, S Mohanan… - Cancer …, 2013‏ - aacrjournals.org
Glioblastoma multiforme contains a subpopulation of cancer stem–like cells (CSC) believed
to underlie tumorigenesis and therapeutic resistance. Recent studies have localized CSCs …

Glial cell diversity and methamphetamine-induced neuroinflammation in human cerebral organoids

J Dang, SK Tiwari, K Agrawal, H Hui, Y Qin… - Molecular …, 2021‏ - nature.com
Methamphetamine (METH) is a potent stimulant that induces a euphoric state but also
causes cognitive impairment, neurotoxicity and neurodevelopmental deficits. Yet, the …