Long non-coding RNAs (lncRNAs) are emerging as new players in the cancer paradigm
demonstrating potential roles in both oncogenic and tumor suppressive pathways. These …

Unraveling the gene expression networks governing cancer initiation and development is
essential while remains largely uncompleted. With the innovations in RNA-seq technologies …

With the development of whole genome and transcriptome sequencing technologies, long
noncoding RNAs (lncRNAs) have received increased attention. Multiple studies indicate that …

Tiling array and novel sequencing technologies have made available the transcription
profile of the entire human genome. However, the extent of transcription and the function of …

Patients with cancer carry somatic sequence variants in their tumour in addition to the
germline variants in their inherited genome. Although variants in protein-coding regions …

Osteosarcoma is a highly aggressive cancer for which treatment has remained essentially
unchanged for more than 30 years. Osteosarcoma is characterized by widespread and …

Adrenocortical carcinomas (ACCs) are aggressive cancers originating in the cortex of the
adrenal gland. Despite overall poor prognosis, ACC outcome is heterogeneous,. We …

The conventional view of gene regulation in biology has centered around protein-coding
genes via the central dogma of DNA→ mRNA→ protein. The discovery of thousands of long …

Tumor suppressor genes (TSGs) are a major type of gatekeeper genes in the cell growth. A
knowledgebase with the systematic collection and curation of TSGs in multiple cancer types …

Large numbers of long RNAs with little or no protein-coding potential [long noncoding RNAs
(lncRNAs)] are being identified in eukaryotes. In parallel, increasing data describing the …