Pursuing effective vaccines against cattle diseases caused by apicomplexan protozoa

M Florin-Christensen, L Schnittger, RG Bastos… - CABI …, 2021 - cabidigitallibrary.org
Apicomplexan parasites are responsible for important livestock diseases that affect the
production of much needed protein resources, and those transmissible to humans pose a …

[HTML][HTML] Neosporosis: an overview of its molecular epidemiology and pathogenesis

A Khan, JS Shaik, P Sikorski, JP Dubey, ME Grigg - Engineering, 2020 - Elsevier
Abstract Neospora caninum (N. caninum), a cyst-forming protozoan parasite, is a major
cause of bovine abortions and neonatal mortality worldwide. N. caninum has a broad …

Neospora caninum dense granule protein 7 regulates the pathogenesis of neosporosis by modulating host immune response

Y Nishikawa, N Shimoda, RM Fereig… - Applied and …, 2018 - journals.asm.org
Neospora caninum is a protozoan parasite closely related to Toxoplasma gondii.
Neosporosis caused by N. caninum is considered one of the main causes of abortion in …

[HTML][HTML] NcGRA7 and NcROP40 Play a Role in the Virulence of Neospora caninum in a Pregnant Mouse Model

L Rico-San Román, R Amieva, J Regidor-Cerrillo… - Pathogens, 2022 - mdpi.com
The intraspecific variability among Neospora caninum isolates in their in vitro behaviour and
in vivo virulence has been widely studied. In particular, transcriptomic and proteomic …

Combination therapy against multidrug resistance

M Marimani - Combination Therapy Against Multidrug Resistance, 2020 - Elsevier
Many microbial pathogens have developed different strategies that enable them to survive
and flourish in the presence of antimicrobial agents that would otherwise kill or inhibit their …

[HTML][HTML] Characterization of Neospora caninum virulence factors NcGRA7 and NcROP40 in bovine target cells

L Rico-San Román, R Amieva, P Horcajo… - Veterinary …, 2023 - Elsevier
Bovine neosporosis is one of the major causes of reproductive failure in cattle worldwide,
and differences in virulence between isolates have been widely shown. However, the …

Genetic manipulation toolkits in apicomplexan parasites

Z Niu, L Xue, X Yin, B Shen - Zoonoses, 2022 - scienceopen.com
Apicomplexan parasites are a group of intracellular pathogens of great medical and
veterinary importance, including Toxoplasma gondii and Plasmodium, which cause …

Are genetically modified protozoa eligible for ATMP status? Concerning the legal categorization of an oncolytic protozoan drug candidate

M Guerriaud, C Poupet, Z Lakhrif, E Kohli, N Moiré - Gene Therapy, 2024 - nature.com
Neospora caninum is an obligate intracellular protozoan that affects several animal species.
It is not pathogenic for humans, and its ability to infect and lyse a variety of cells and …

Efficient gene knockout and knockdown systems in Neospora caninum enable rapid discovery and functional assessment of novel proteins

TWP Mineo, JH Chern, AC Thind, CM Mota… - Msphere, 2022 - journals.asm.org
The development of molecular genetics has greatly enhanced the study of the biology and
pathology associated with parasites of the phylum Apicomplexa. While the molecular tools …

Genome editing in apicomplexan parasites: Current status, challenges, and future possibilities

E Webi, HM Abkallo, G Obiero, P Ndegwa… - The CRISPR …, 2024 - liebertpub.com
Clustered regularly interspaced short palindromic repeats (CRISPR)–CRISPR-associated
protein (Cas) technology has revolutionized genome editing across various biological …