Degenerative disorders of joints, especially osteoarthritis (OA), result in persistent pain and
disability and high costs to society. Nevertheless, the molecular mechanisms of OA have not …

Objectives Our goal is to review design strategies for the fabrication of calcium phosphate
ceramic scaffolds (CPS), in light of their transient role in bone tissue engineering and …

Background Adipose-derived stem cells (ASCs) have been introduced as an alternative to
bone marrow mesenchymal stem cells (BMSCs) for cell-based therapy. However, different …

The regeneration of articular cartilage, which scarcely shows innate self-healing ability, is a
great challenge in clinical treatment. Stem cell-derived exosomes (SC-Exos), an important …

Extracellular vesicles (EVs) secreted by cells present an attractive strategy for develo**
new therapies, but progress in the field is limited by several issues: The quality of the EVs …

There is currently an unmet need for the supply of autologous, patient-specific stem cells for
regenerative therapies in the clinic. Mesenchymal stem cell differentiation can be driven by …

Extracellular vesicles (EV) consist of exosomes, which are released upon fusion of the
multivesicular body with the cell membrane, and microvesicles, which are released directly …

The use of cryopreserved unmatched allogeneic mesenchymal stromal cells (MSCs) for
treatment of steroid-resistant graft-versus-host disease has become medical practice in …

Background Inflammation is a key contributor to central nervous system (CNS) injury such as
stroke, and is a major target for therapeutic intervention. Effective treatments for CNS injuries …

The response of osteoprogenitors to calcium (Ca2+) is of primary interest for both normal
bone homeostasis and the clinical field of bone regeneration. The latter makes use of …