Quorum quenching enzymes and their effects on virulence, biofilm, and microbiomes: a review of recent advances
Introduction Numerous bacterial behaviors are regulated by a cell-density dependent
mechanism known as Quorum Sensing (QS). QS relies on communication between bacterial …
mechanism known as Quorum Sensing (QS). QS relies on communication between bacterial …
Biotechnological applications of quorum quenching enzymes
Numerous bacteria use quorum sensing (QS) to synchronize their behavior and monitor
their population density. They use signaling molecules known as autoinducers (AI's) that are …
their population density. They use signaling molecules known as autoinducers (AI's) that are …
Engineering acyl-homoserine lactone-interfering enzymes toward bacterial control
Enzymes able to degrade or modify acyl-homoserine lactones (AHLs) have drawn
considerable interest for their ability to interfere with the bacterial communication process …
considerable interest for their ability to interfere with the bacterial communication process …
Current and emerging strategies for organophosphate decontamination: special focus on hyperstable enzymes
P Jacquet, D Daudé, J Bzdrenga, P Masson… - … Science and Pollution …, 2016 - Springer
Organophosphorus chemicals are highly toxic molecules mainly used as pesticides. Some
of them are banned warfare nerve agents. These compounds are covalent inhibitors of …
of them are banned warfare nerve agents. These compounds are covalent inhibitors of …
Catalytic Redundancies and Conformational Plasticity Drives Selectivity and Promiscuity in Quorum Quenching Lactonases
Several enzymes from the metallo-β-lactamase-like family of lactonases (MLLs) degrade N-
acyl L-homoserine lactones (AHLs). They play a role in a microbial communication system …
acyl L-homoserine lactones (AHLs). They play a role in a microbial communication system …
Structural and biochemical characterization of AaL, a quorum quenching lactonase with unusual kinetic properties
C Bergonzi, M Schwab, T Naik, D Daudé… - Scientific reports, 2018 - nature.com
Quorum quenching lactonases are enzymes that are capable of disrupting bacterial
signaling based on acyl homoserine lactones (AHL) via their enzymatic degradation. In …
signaling based on acyl homoserine lactones (AHL) via their enzymatic degradation. In …
Rational engineering of a native hyperthermostable lactonase into a broad spectrum phosphotriesterase
The redesign of enzyme active sites to alter their function or specificity is a difficult yet
appealing challenge. Here we used a structure-based design approach to engineer the …
appealing challenge. Here we used a structure-based design approach to engineer the …
Signal disruption leads to changes in bacterial community population
The disruption of bacterial signaling (quorum quenching) has been proven to be an
innovative approach to influence the behavior of bacteria. In particular, lactonase enzymes …
innovative approach to influence the behavior of bacteria. In particular, lactonase enzymes …
Crystal structure of VmoLac, a tentative quorum quenching lactonase from the extremophilic crenarchaeon Vulcanisaeta moutnovskia
A new representative of the Phosphotriesterase-Like Lactonases (PLLs) family from the
hyperthermophilic crenarchaeon Vulcanisaeta moutnovskia has been characterized and …
hyperthermophilic crenarchaeon Vulcanisaeta moutnovskia has been characterized and …
Effects of signal disruption depends on the substrate preference of the lactonase
Many bacteria produce and use extracellular signaling molecules such as acyl homoserine
lactones (AHLs) to communicate and coordinate behavior in a cell-density dependent …
lactones (AHLs) to communicate and coordinate behavior in a cell-density dependent …