Computational network biology: data, models, and applications
Biological entities are involved in intricate and complex interactions, in which uncovering the
biological information from the network concepts are of great significance. Benefiting from …
biological information from the network concepts are of great significance. Benefiting from …
In silico polypharmacology of natural products
Natural products with polypharmacological profiles have demonstrated promise as novel
therapeutics for various complex diseases, including cancer. Currently, many gaps exist in …
therapeutics for various complex diseases, including cancer. Currently, many gaps exist in …
Network-based drug repurposing for novel coronavirus 2019-nCoV/SARS-CoV-2
Human coronaviruses (HCoVs), including severe acute respiratory syndrome coronavirus
(SARS-CoV) and 2019 novel coronavirus (2019-nCoV, also known as SARS-CoV-2), lead …
(SARS-CoV) and 2019 novel coronavirus (2019-nCoV, also known as SARS-CoV-2), lead …
A comprehensive genomic pan-cancer classification using The Cancer Genome Atlas gene expression data
Abstract Background The Cancer Genome Atlas (TCGA) has generated comprehensive
molecular profiles. We aim to identify a set of genes whose expression patterns can …
molecular profiles. We aim to identify a set of genes whose expression patterns can …
Escape artists of the X chromosome
Inactivation of one X chromosome in mammalian females achieves dosage compensation
between XX females and XY males; however, over 15% of human X-linked genes continue …
between XX females and XY males; however, over 15% of human X-linked genes continue …
Precision medicine and driver mutations: computational methods, functional assays and conformational principles for interpreting cancer drivers
At the root of the so-called precision medicine or precision oncology, which is our focus
here, is the hypothesis that cancer treatment would be considerably better if therapies were …
here, is the hypothesis that cancer treatment would be considerably better if therapies were …
BCL6 is regulated by the MAPK/ELK1 axis and promotes KRAS-driven lung cancer
K Li, Y Liu, Y Ding, Z Zhang, J Feng… - The Journal of …, 2022 - Am Soc Clin Investig
Mutational activation of KRAS is a common oncogenic event in lung cancer, yet effective
therapies are still lacking. Here, we identify B cell lymphoma 6 (BCL6) as a lynchpin in …
therapies are still lacking. Here, we identify B cell lymphoma 6 (BCL6) as a lynchpin in …
Vital node identification in hypergraphs via gravity model
Hypergraphs that can depict interactions beyond pairwise edges have emerged as an
appropriate representation for modeling polyadic relations in complex systems. With the …
appropriate representation for modeling polyadic relations in complex systems. With the …
[HTML][HTML] Medulloblastoma: molecular classification-based personal therapeutics
TC Archer, EL Mahoney, SL Pomeroy - Neurotherapeutics, 2017 - Elsevier
Recent advances in cancer genomics have revealed 4 distinct subgroups of
medulloblastomas, each with unique transcription profiles, DNA alterations and clinical …
medulloblastomas, each with unique transcription profiles, DNA alterations and clinical …
When the Lyon (ized chromosome) roars: ongoing expression from an inactive X chromosome
L Carrel, CJ Brown - … Transactions of the Royal Society B …, 2017 - royalsocietypublishing.org
A tribute to Mary Lyon was held in October 2016. Many remarked about Lyon's foresight
regarding many intricacies of the X-chromosome inactivation process. One such example is …
regarding many intricacies of the X-chromosome inactivation process. One such example is …