Microglia in depression: an overview of microglia in the pathogenesis and treatment of depression
Major depressive disorder is a highly debilitating psychiatric disorder involving the
dysfunction of different cell types in the brain. Microglia are the predominant resident …
dysfunction of different cell types in the brain. Microglia are the predominant resident …
Chronic stress and oxidative stress as common factors of the pathogenesis of depression and Alzheimer's disease: The role of antioxidants in prevention and …
G Juszczyk, J Mikulska, K Kasperek, D Pietrzak… - Antioxidants, 2021 - mdpi.com
There is a growing body of scientific research showing the link between depression and
dementia in Alzheimer's disease (AD). The chronic stress contributes to the formation of …
dementia in Alzheimer's disease (AD). The chronic stress contributes to the formation of …
Melatonin attenuates LPS-induced acute depressive-like behaviors and microglial NLRP3 inflammasome activation through the SIRT1/Nrf2 pathway
Inflammation is a crucial component of various stress-induced responses that contributes to
the pathogenesis of major depressive disorder (MDD). Depressive-like behavior (DLB) is …
the pathogenesis of major depressive disorder (MDD). Depressive-like behavior (DLB) is …
Cortisol and major depressive disorder—translating findings from humans to animal models and back
Major depressive disorder (MDD) is a global problem for which current pharmacotherapies
are not completely effective. Hypothalamic–pituitary–adrenal (HPA) axis dysfunction has …
are not completely effective. Hypothalamic–pituitary–adrenal (HPA) axis dysfunction has …
Animal models of depression: what can they teach us about the human disease?
Depression is apparently the most common psychiatric disease among the mood disorders
affecting about 10% of the adult population. The etiology and pathogenesis of depression …
affecting about 10% of the adult population. The etiology and pathogenesis of depression …
Ibrutinib alleviates LPS-induced neuroinflammation and synaptic defects in a mouse model of depression
Previous studies have demonstrated a close association between an altered immune
system and major depressive disorders, and inhibition of neuroinflammation may represent …
system and major depressive disorders, and inhibition of neuroinflammation may represent …
Resveratrol and depression in animal models: a systematic review of the biological mechanisms
A Moore, J Beidler, MY Hong - Molecules, 2018 - mdpi.com
Depression is currently treated by pharmacotherapies that can elicit debilitating side effects
for patients. Novel treatment options with limited side effects are currently being researched …
for patients. Novel treatment options with limited side effects are currently being researched …
The role of oxidative and nitrosative stress in accelerated aging and major depressive disorder
Major depressive disorder (MDD) affects millions of individuals and is highly comorbid with
many age-associated diseases such as diabetes mellitus, immune-inflammatory …
many age-associated diseases such as diabetes mellitus, immune-inflammatory …
Targeting autophagy and neuroinflammation pathways with plant‐derived natural compounds as potential antidepressant agents
T Mokhtari - Phytotherapy Research, 2022 - Wiley Online Library
Major depressive disorder (MDD) is a life‐threatening disease that presents several
characteristics. The pathogenesis of depression still remains poorly understood. Moreover …
characteristics. The pathogenesis of depression still remains poorly understood. Moreover …
2021 ISHEN guidelines on animal models of hepatic encephalopathy
This working group of the International Society of Hepatic Encephalopathy and Nitrogen
Metabolism (ISHEN) was commissioned to summarize and update current efforts in the …
Metabolism (ISHEN) was commissioned to summarize and update current efforts in the …