The three interacting components of the outer blood-retinal barrier are the retinal pigment
epithelium (RPE), choriocapillaris, and Bruch's membrane, the extracellular matrix that lies …

The development of therapeutics for effective treatments of retinal diseases is significantly
constrained by various biological barriers. We herein report a nanomedicine strategy to …

Naturally derived polymeric biomaterials, such as collagens, silks, elastins, alginates, and
fibrins are utilized in tissue engineering due to their biocompatibility, bioactivity, and tunable …

Cell replacement therapies are often enhanced by utilizing polymer scaffolds to improve
retention or direct cell orientation and migration. Obstacles to refinement of such polymer …

Retinal pigment epithelium (RPE) cells grown on a scaffold, an RPE patch, have potential to
ameliorate visual impairment in a limited number of retinal degenerative conditions. This …

Human pluripotent stem cell-derived retinal pigment epithelium (iRPE) is an attractive cell
source for disease modeling and cell replacement therapy of retinal disorders with RPE …

Age-related ocular diseases, such as age-related macular degeneration (AMD), diabetic
retinopathy, and glaucoma, result in life-long functional deficits and enormous global health …

Purpose The purpose of this work was to develop, characterize and compare electrospun
nanofiber inserts (ENIs) and solvent cast polymeric inserts (SCIs) for ocular drug delivery …

In recent years, regenerative medicine is gaining momentum and is giving hopes for
restoring function of diseased, damaged, and aged tissues and organs and nanotechnology …

Age-related macular degeneration (AMD) is a complex neurodegenerative visual disorder
that causes profound physical and psychosocial effects. Visual impairment in AMD is caused …