Many transition metal complexes have unique physicochemical properties that can be
efficiently exploited in medicinal chemistry for cancer treatment. Traditionally, double …

Faithful transmission and maintenance of genetic material is primarily fulfilled by DNA
polymerases. During DNA replication, these enzymes catalyze incorporation of …

Implant-associated infections (IAIs) pose a significant threat to orthopedic surgeries. Bacteria
colonizing the surface of implants disrupt bone formation-related cells and interfere with the …

CRISPR-Cas are adaptive immune systems in bacteria and archaea that utilize CRISPR
RNA-guided surveillance complexes to target complementary RNA or DNA for destruction …

Enzymes are highly evolved catalysts that perform their tasks with high efficiency. 1 Hence,
they may constitute a very attractive reference in the development of a synthetic catalyst. The …

At the core of the CRISPR–Cas9 genome-editing technology, the endonuclease Cas9
introduces site-specific breaks in DNA. However, precise mechanistic information to …

CRISPR-Cas9 has become a facile genome editing technology, yet the structural and
mechanistic features underlying its function are unclear. Here, we perform extensive …

CRISPR-Cas9 is a cutting-edge genome editing technology, which uses the endonuclease
Cas9 to introduce mutations at desired sites of the genome. This revolutionary tool is …

CRISPR-Cas9 technology has been widely used for genome engineering. Its RNA-guided
endonuclease Cas9 binds specifically to target DNA and then cleaves the two DNA strands …

Dear editors In the battle between CRISPR-Cas* prokaryotic immune systems and the
elements that they target, a diverse array of ''anti-CRISPR''proteins have evolved. These …