DNA methylation is of paramount importance for mammalian embryonic development. DNA
methylation has numerous functions: it is implicated in the repression of transposons and …

Transposable elements (TEs) are mobile DNA elements that comprise almost 50% of
mammalian genomic sequence. TEs are capable of making additional copies of themselves …

A remarkable epigenetic remodelling process occurs shortly after fertilization, which restores
totipotency to the zygote. This involves global DNA demethylation, chromatin remodelling …

Transposable element (TE)-derived sequences are ubiquitous in most eukaryotic genomes
known to date. Because their expression and mobility can lead to genomic instability …

Since the discovery of transposons, their sheer abundance in host genomes has puzzled
many. While historically viewed as largely harmless 'parasitic'DNAs during evolution …

Transposable elements (TEs) are genetic elements with the ability to mobilize and replicate
themselves in a genome. Mammalian genomes are dominated by TEs, which can reach …

Human preimplantation development involves extensive remodeling of RNA expression and
splicing. However, its transcriptome has been compiled using short-read sequencing data …

Retrotransposons encompass half of the human genome and contribute to the formation of
heterochromatin, which provides nuclear structure and regulates gene expression. Here, we …

There is considerable interest in understanding the effect of transposable elements (TEs) on
embryonic development. Studies in humans and mice are limited by the difficulty of working …

Transposable elements (TEs) are genetic elements capable of changing position within the
genome. Although their mobilization can constitute a threat to genome integrity, nearly half …