Aneuploidy, an abnormal chromosome composition, is a major contributor to cancer
development and progression and an important determinant of cancer therapeutic …

Chromosomal instability (CIN) is a hallmark of cancer and is associated with tumor cell
malignancy. CIN triggers a chain reaction in cells leading to chromosomal abnormalities …

Aneuploidy, or a change in the number of whole chromosomes or chromosome arms, is a
near-universal feature of cancer. Chromosomes affected by aneuploidy are not random, with …

Aneuploidy is prevalent in cancer and associates with fitness advantage and poor patient
prognosis. Yet, experimentally induced aneuploidy initially leads to adverse effects and …

The AurkA serine/threonine kinase is a key regulator of cell division controlling mitotic entry,
centrosome maturation, and chromosome segregation. The microtubule-associated protein …

Aneuploidy, the presence of an aberrant number of chromosomes, has been associated with
tumorigenesis for over a century. More recently, advances in karyoty** techniques have …

Centromere pairing is crucial for synapsis in meiosis. This study delves into the Skp1-Cullin1-
F-box protein (SCF) E3 ubiquitin ligase complex, specifically focusing on F-box protein 47 …

Simple Summary Sarcopenia refers to a progressive and systemic reduction in skeletal
muscle mass and strength and is a primary component of cancer cachexia. This …

Chromosome segregation in female germ cells and early embryonic blastomeres is known
to be highly prone to errors. The resulting aneuploidy is therefore the most frequent cause of …

Aneuploidy, the major cause of miscarriages in humans, is pervasive in early embryos but
robustly dampened during development, allowing for healthy births. Later in life, aneuploidy …