Methanol-based industrial biotechnology: current status and future perspectives of methylotrophic bacteria
Methanol is one of the building blocks in the chemical industry and can be synthesized
either from petrochemical or renewable resources, such as biogas. Bioprocess technology …
either from petrochemical or renewable resources, such as biogas. Bioprocess technology …
The protein cost of metabolic fluxes: prediction from enzymatic rate laws and cost minimization
Bacterial growth depends crucially on metabolic fluxes, which are limited by the cell's
capacity to maintain metabolic enzymes. The necessary enzyme amount per unit flux is a …
capacity to maintain metabolic enzymes. The necessary enzyme amount per unit flux is a …
From network models to network responses: integration of thermodynamic and kinetic properties of yeast genome-scale metabolic networks
Many important problems in cell biology arise from the dense nonlinear interactions
between functional modules. The importance of mathematical modelling and computer …
between functional modules. The importance of mathematical modelling and computer …
Pseudomonas aeruginosa reverse diauxie is a multidimensional, optimized, resource utilization strategy
Pseudomonas aeruginosa is a globally-distributed bacterium often found in medical
infections. The opportunistic pathogen uses a different, carbon catabolite repression (CCR) …
infections. The opportunistic pathogen uses a different, carbon catabolite repression (CCR) …
Antimalarial drug targets in Plasmodium falciparum predicted by stage-specific metabolic network analysis
C Huthmacher, A Hoppe, S Bulik, HG Holzhütter - BMC systems biology, 2010 - Springer
Background Despite enormous efforts to combat malaria the disease still afflicts up to half a
billion people each year of which more than one million die. Currently no approved vaccine …
billion people each year of which more than one million die. Currently no approved vaccine …
Competitive resource allocation to metabolic pathways contributes to overflow metabolisms and emergent properties in cross-feeding microbial consortia
Resource scarcity is a common stress in nature and has a major impact on microbial
physiology. This review highlights microbial acclimations to resource scarcity, focusing on …
physiology. This review highlights microbial acclimations to resource scarcity, focusing on …
What mRNA abundances can tell us about metabolism
A Hoppe - Metabolites, 2012 - mdpi.com
Inferring decreased or increased metabolic functions from transcript profiles is at first sight a
bold and speculative attempt because of the functional layers in between: proteins …
bold and speculative attempt because of the functional layers in between: proteins …
A computational analysis of protein interactions in metabolic networks reveals novel enzyme pairs potentially involved in metabolic channeling
C Huthmacher, C Gille, HG Holzhütter - Journal of theoretical biology, 2008 - Elsevier
Protein–protein interactions are operative at almost every level of cell structure and function
as, for example, formation of sub-cellular organelles, packaging of chromatin, muscle …
as, for example, formation of sub-cellular organelles, packaging of chromatin, muscle …
[HTML][HTML] Milk metabolites and their genetic variability
The composition of milk is crucial to evaluate milk performance and quality measures. Milk
components partly contribute to breeding scores, and they can be assessed to judge …
components partly contribute to breeding scores, and they can be assessed to judge …
Systems analysis of microbial adaptations to simultaneous stresses
Microbes live in multi-factorial environments and have evolved under a variety of concurrent
stresses including resource scarcity. Their metabolic organization is a reflection of their …
stresses including resource scarcity. Their metabolic organization is a reflection of their …