Biocatalytic cascades operating on macromolecular scaffolds and in confined environments

M Vázquez-González, C Wang, I Willner - Nature Catalysis, 2020 - nature.com
Biocatalytic cascades guide complex, efficient and selective intracellular transformations.
These unique features originate from the spatial organization of the biocatalysts in confined …

Bioinspired polymer vesicles and membranes for biological and medical applications

CG Palivan, R Goers, A Najer, X Zhang, A Car… - Chemical society …, 2016 - pubs.rsc.org
Biological membranes play an essential role in living organisms by providing stable and
functional compartments, preserving cell architecture, whilst supporting signalling and …

Fabricating covalent organic framework capsules with commodious microenvironment for enzymes

M Li, S Qiao, Y Zheng, YH Andaloussi… - Journal of the …, 2020 - ACS Publications
Enzyme immobilization has been demonstrated to be a favorable protocol to promote
industrialization of biomacromolecules. Despite tremendous efforts to develop new …

Stimuli-responsive polymersomes for biomedical applications

X Hu, Y Zhang, Z **e, X **g, A Bellotti, Z Gu - Biomacromolecules, 2017 - ACS Publications
Polymersomes, the structural analogues of liposomes, are hollow structures enclosed by a
bilayer membrane made from amphiphilic copolymers. Polymersomes have been proposed …

Engineering functional polymer capsules toward smart nanoreactors

J Gaitzsch, X Huang, B Voit - Chemical reviews, 2016 - ACS Publications
The design and construction of integrated chemical ensembles for studying complex
biological systems is attracting considerable interest in a wide range of research …

Recent progress in functionalized and targeted polymersomes and chimeric polymeric nanotheranostic platforms for cancer therapy

M Beygi, F Oroojalian, SS Hosseini… - Progress in Materials …, 2023 - Elsevier
The majority of advances in cancer therapy have been achieved based on developments in
public awareness, as well as novel diagnostic and therapeutic modalities. Treatment …

Synthetic cells revisited: Artificial cell construction using polymeric building blocks

V Maffeis, L Heuberger, A Nikoletić… - Advanced …, 2024 - Wiley Online Library
The exponential growth of research on artificial cells and organelles underscores their
potential as tools to advance the understanding of fundamental biological processes. The …

Cascade catalysis–strategies and challenges en route to preparative synthetic biology

J Muschiol, C Peters, N Oberleitner… - Chemical …, 2015 - pubs.rsc.org
Nature's smartness and efficient assembling cascade type reactions inspired biologists and
chemists all around the world. Tremendous effort has been directed towards the …

Enzyme‐responsive polymeric vesicles for bacterial‐strain‐selective delivery of antimicrobial agents

Y Li, G Liu, X Wang, J Hu, S Liu - … Chemie International Edition, 2016 - Wiley Online Library
Antimicrobial resistance poses serious public health concerns and antibiotic misuse/abuse
further complicates the situation; thus, it remains a considerable challenge to …

Permeable protein-loaded polymersome cascade nanoreactors by polymerization-induced self-assembly

LD Blackman, S Varlas, MC Arno, A Fayter… - ACS macro …, 2017 - ACS Publications
Enzyme loading of polymersomes requires permeability to enable them to interact with the
external environment, typically requiring addition of complex functionality to enable porosity …