The use of computational fluid dynamics in the development of ventricular assist devices

KH Fraser, ME Taskin, BP Griffith, ZJ Wu - Medical engineering & physics, 2011 - Elsevier
Progress in the field of prosthetic cardiovascular devices has significantly contributed to the
rapid advancements in cardiac therapy during the last four decades. The concept of …

[HTML][HTML] Occlusive thrombosis in arteries

D Kim, C Bresette, Z Liu, DN Ku - APL bioengineering, 2019 - pubs.aip.org
Thrombus formation in major arteries is life threatening. In this review article, we discuss
how an arterial thrombus can form under pathologically high shear stresses, with bonding …

A quantitative comparison of mechanical blood damage parameters in rotary ventricular assist devices: shear stress, exposure time and hemolysis index

KH Fraser, T Zhang, ME Taskin, BP Griffith, ZJ Wu - 2012 - asmedigitalcollection.asme.org
Ventricular assist devices (VADs) have already helped many patients with heart failure but
have the potential to assist more patients if current problems with blood damage (hemolysis …

Acquired von Willebrand syndrome in patients with extracorporeal life support (ECLS)

C Heilmann, U Geisen, F Beyersdorf, L Nakamura… - Intensive care …, 2012 - Springer
Purpose Extracorporeal life support (ECLS) is used for patients with refractory heart failure
with or without respiratory failure. This temporary support is provided by blood pumps which …

An extended pattern search approach to wind farm layout optimization

BL Du Pont, J Cagan - 2012 - asmedigitalcollection.asme.org
An extended pattern search approach is presented for the optimization of the placement of
wind turbines on a wind farm. Problem-specific extensions infuse stochastic characteristics …

Flow features and device‐induced blood trauma in CF‐VADs under a pulsatile blood flow condition: a CFD comparative study

Z Chen, SK Jena, GA Giridharan… - … journal for numerical …, 2018 - Wiley Online Library
In this study, the flow features and device‐associated blood trauma in 4 clinical ventricular
assist devices (VADs; 2 implantable axial VADs, 1 implantable centrifugal VAD, and 1 …

Quantification of shear‐induced platelet activation: high shear stresses for short exposure time

J Ding, Z Chen, S Niu, J Zhang, NK Mondal… - Artificial …, 2015 - Wiley Online Library
Thrombosis and thromboembolism are the life‐threatening clinical complications for patients
supported or treated with prosthetic cardiovascular devices. The high mechanical shear …

Comparison of two platelet activation markers using flow cytometry after in vitro shear stress exposure of whole human blood

Q Lu, RA Malinauskas - Artificial organs, 2011 - Wiley Online Library
Platelet activation is the initiating step to thromboembolic complications in blood‐contacting
medical devices. Currently, there are no widely accepted testing protocols or relevant …

Analysis of rotary ventricular assist devices using CFD technique—a review

PK Shukla, R Mishra, RP Tewari - Proceedings of the …, 2023 - journals.sagepub.com
With the increasing focus on reducing deaths because of heart ailments, considerable
emphasis has been directed toward the development of ventricular assist devices (VADs) …

Distribution and history of extensional stresses on vWF surrogate molecules in turbulent flow

OL Pham, SE Feher, QT Nguyen, DV Papavassiliou - Scientific Reports, 2022 - nature.com
The configuration of proteins is critical for their biochemical behavior. Mechanical stresses
that act on them can affect their behavior leading to the development of decease. The von …