Exploiting the biogenesis of extracellular vesicles for bioengineering and therapeutic cargo loading

J Rädler, D Gupta, A Zickler, SEL Andaloussi - Molecular Therapy, 2023 - cell.com
Extracellular vesicles (EVs) are gaining increasing attention for diagnostic and therapeutic
applications in various diseases. These natural nanoparticles benefit from favorable safety …

Challenges in exosome isolation and analysis in health and disease

N Ludwig, TL Whiteside, TE Reichert - International journal of molecular …, 2019 - mdpi.com
A growing body of evidence emphasizes the important role exosomes in different
physiological and pathological conditions. Exosomes, virus-size extracellular vesicles (EVs) …

Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches

JA Welsh, DCI Goberdhan, L O'Driscoll… - Journal of …, 2024 - Wiley Online Library
Extracellular vesicles (EVs), through their complex cargo, can reflect the state of their cell of
origin and change the functions and phenotypes of other cells. These features indicate …

Molecular evaluation of five different isolation methods for extracellular vesicles reveals different clinical applicability and subcellular origin

RE Veerman, L Teeuwen, P Czarnewski… - Journal of …, 2021 - Wiley Online Library
Extracellular vesicles (EVs) are increasingly tested as therapeutic vehicles and biomarkers,
but still EV subtypes are not fully characterised. To isolate EVs with few co‐isolated entities …

The potential of metabolomics in biomedical applications

V Gonzalez-Covarrubias, E Martínez-Martínez… - Metabolites, 2022 - mdpi.com
The metabolome offers a dynamic, comprehensive, and precise picture of the phenotype.
Current high-throughput technologies have allowed the discovery of relevant metabolites …

Development of extracellular vesicle therapeutics: Challenges, considerations, and opportunities

B Claridge, J Lozano, QH Poh… - Frontiers in Cell and …, 2021 - frontiersin.org
Extracellular vesicles (EVs) hold great promise as therapeutic modalities due to their
endogenous characteristics, however, further bioengineering refinement is required to …

Apoptotic bodies for advanced drug delivery and therapy

M Zhou, YJ Li, YC Tang, XY Hao, WJ Xu… - Journal of Controlled …, 2022 - Elsevier
Extracellular vesicles (EVs) have emerged as promising candidates for multiple biomedical
applications. Major types of EVs include exosomes, microvesicles, and apoptotic bodies …

Extracellular vesicles—connecting kingdoms

E Woith, G Fuhrmann, MF Melzig - International journal of molecular …, 2019 - mdpi.com
It is known that extracellular vesicles (EVs) are shed from cells of almost every type of cell or
organism, showing their ubiquity in all empires of life. EVs are defined as naturally released …

Technological advances towards extracellular vesicles mass production

A Grangier, J Branchu, J Volatron, M Piffoux… - Advanced Drug Delivery …, 2021 - Elsevier
Extracellular vesicles (EVs) are becoming essential actors in bio-therapeutics, as much for
their regenerative or immunomodulatory properties as for their potential as cargo delivery …

The tissue origin effect of extracellular vesicles on cartilage and bone regeneration

Q Li, H Yu, M Sun, P Yang, X Hu, Y Ao, J Cheng - Acta Biomaterialia, 2021 - Elsevier
Direct implantation of mesenchymal stem cells (MSCs) for cartilage and bone tissue
engineering faces challenges, such as immune rejection and loss of cellular viability or …