Similarities in neocortical circuit organization across areas and species suggest a common
strategy to process diverse types of information, including sensation from diverse modalities …

Corticostriatal projections are essential components of forebrain circuits and are widely
involved in motivated behaviour. These axonal projections are formed by two distinct …

The sensory cortex contains a wide array of neuronal types, which are connected together
into complex but partially stereotyped circuits. Sensory stimuli trigger cascades of electrical …

The molecular diversification of cell surface molecules has long been postulated to impart
specific surface identities on neuronal cell types. The existence of unique cell surface …

Neuron-glia interactions play a critical role in the regulation of synapse formation and circuit
assembly. Here we demonstrate that canonical Sonic hedgehog (Shh) pathway signaling in …

Astrocytes are specialized and heterogeneous cells that contribute to central nervous
system function and homeostasis. However, the mechanisms that create and maintain …

Astrocytes are the most abundant glial cell type in the central nervous system and are
essential to the development, plasticity, and maintenance of neural circuits. Astrocytes are …

The medial prefrontal cortex (mPFC) has been implicated in cognitive and executive
processes including decision making, working memory and behavioral flexibility. Cortical …

Endosomal sorting complex required for transport (ESCRT) complex proteins regulate
biogenesis and release of extracellular vesicles (EVs), which enable cell-to-cell …

The generation of purposive movement by mammals involves coordinated activity in the
corticospinal and corticostriatal systems, which are involved in different aspects of motor …