In vitro cell cultures are crucial research tools for modeling human development and
diseases. Although the conventional monolayer cell cultures have been widely used in the …

Over the past decade, immunotherapy has become a powerful and evident tool in the fight
against cancers. Notably, the rise of checkpoint blockade using monoclonal antibodies (anti …

Fundamental cancer research and the development of efficacious antineoplastic treatments
both rely on experimental systems in which the relationship between malignant cells and …

Personalized cancer therapy applies specific treatments to each patient. Using personalized
tumor models with similar characteristics to the original tumors may result in more accurate …

Cancer is a major public health problem worldwide. Gastrointestinal cancers account for
approximately one-third of the total global cancer incidence and mortality. Historically, the …

Microfluidic cell cultures are ideally positioned to become the next generation of in vitro
diagnostic tools for biomedical research, where key biological processes such as cell …

Cancer immunotherapy has achieved remarkable success over the past decade by
modulating patients' own immune systems and unleashing pre-existing immunity. However …

Most cancer patients do not die from the primary tumor but from its metastasis. Current in
vitro and in vivo cancer models are incapable of satisfactorily predicting the outcome of …

The tumor microenvironment (TME) typically comprises cancer cells, tumor vasculature,
stromal components like fibroblasts, and host immune cells that assemble to support …

In recognition of the enormous potential of immunotherapies against cancer, research into
the interactions between tumor and immune cells has accelerated, leading to the recent FDA …