Osteosarcoma is the most common primary bone malignancy in adolescents. Its high
propensity to metastasize is the leading cause for treatment failure and poor prognosis …

The bone microenvironment is an ideal fertile soil for both primary and secondary tumors to
seed. The occurrence and development of osteosarcoma, as a primary bone tumor, is …

During the last decade, there has been great interest in elucidating the biological role of
extracellular vesicles (EVs), particularly, their hormone-like role in cell-to-cell …

Cell migration is essential for the development and maintenance of multicellular organisms,
contributing to embryogenesis, wound healing, immune response, and other critical …

Multiphoton fluorescence microscopy (MPFM) has been a game-changer for optical
imaging, particularly for studying biological tissues deep within living organisms. MPFM …

Extracellular vesicles (EVs) have numerous potential applications in the field of healthcare
and diagnostics, and research into their biological functions is rapidly increasing. Mainly …

Simple Summary Osteosarcomas are heterogeneous bone tumors with complex genetic and
chromosomic alterations. The numerous patients with metastatic osteosarcoma have a very …

Bone microenvironment provides growth and survival signals essential for osteosarcoma
(OS) initiation and progression. OS cells regulate communications inside tumor …

Osteosarcoma (OS) is an aggressive bone tumor that mainly affects children and
adolescents. OS has a strong tendency to relapse and metastasize, resulting in poor …

During tumorigenesis and development, participation of the tumor microenvironment is not
negligible. As an important component in the tumor microenvironment, mesenchymal stem …