OBJECTIVE The Diabetes Control and Complications Trial (DCCT) was designed to test the
glucose hypothesis and determine whether the complications of type 1 diabetes (T1DM) …

Both type 1 and type 2 diabetes have been associated with reduced performance on
multiple domains of cognitive function and with structural abnormalities in the brain. With an …

Background People with type 2 diabetes are at risk of cognitive impairment and brain
atrophy. We aimed to compare the effects on cognitive function and brain volume of …

• If unexplained hypoglycemia is frequent, evaluation for unrecognized celiac and Addison's
disease should be considered (E).• Currently available technologies like CGM, automated …

[en] The article presents a chapter of the guidelines on pediatric diabetes in the International
Society for Pediatric and Adolescent Diabetes (ISPAD) Clinical Practice Consensus …

Background Clinical guidelines differ regarding their recommended blood glucose targets
for patients with type 1 diabetes and recent studies on patients with type 2 diabetes suggest …

Insulin treatment that mimics normal physiological patterns as closely as possible remains
the cardinal principle of treatment for type 1 diabetes. Since the last guidelines were …

Complications (EDIC) Study (2), are celebrating the 30th anniversary since the start of the
DCCT and 20th since the reporting of the DCCT primary results (3). During the past three …

Type 1 diabetes mellitus (T1DM) is a major subtype of diabetes and is usually diagnosed at
a young age with insulin deficiency. The life expectancy of T1DM patients has increased …

Chronic complications of diabetes are due to myriad disorders of numerous metabolic
pathways that are responsible for most of the morbidity and mortality associated with the …