The precise regulation of gene transcription is required to establish and maintain cell type-
specific gene expression programs during multicellular development. In addition to …

Plant homeodomain (PHD) fingers have emerged as one of the largest families of epigenetic
effectors capable of recognizing or 'reading'post-translational histone modifications and …

The mixed-lineage leukemia protein MLL1 is a transcriptional regulator with an essential
role in early development and hematopoiesis. The biological function of MLL1 is mediated …

Aberrations in chromatin dynamics play a fundamental role in tumorigenesis, yet relatively
little is known of the molecular mechanisms linking histone lysine methylation to neoplastic …

Histone covalent modifications regulate many, if not all, DNA-templated processes, including
gene expression and DNA damage response. The biological consequences of histone …

Gene expression is regulated by a number of interrelated posttranslational modifications of
histones, including citrullination. For example, peptidylarginine deminase 4 (PAD4) converts …

In yeast and animals, tri‐and dimethylation of histone H3 at lysine 4 (H3K4me3/2) are
markers of transcriptionally active genes that have recently been shown to be primary …

Chromatin structure is regulated by chromatin remodeling factors, histone exchange, linker
histone association, and histone modification. Covalent modification of histones is an …

First discovered over 60 years ago, post-translational methylation was considered an
irreversible modification until the initial discoveries of demethylase enzymes in 2004. Now …

Localization of the chromosomal passenger complex (CPC) at centromeres during early
mitosis is essential for accurate chromosome segregation and is dependent on the …