Advances in multimodal data fusion in neuroimaging: overview, challenges, and novel orientation
Multimodal fusion in neuroimaging combines data from multiple imaging modalities to
overcome the fundamental limitations of individual modalities. Neuroimaging fusion can …
overcome the fundamental limitations of individual modalities. Neuroimaging fusion can …
[HTML][HTML] Integrating the neurodevelopmental and dopamine hypotheses of schizophrenia and the role of cortical excitation-inhibition balance
OD Howes, E Shatalina - Biological psychiatry, 2022 - Elsevier
The neurodevelopmental and dopamine hypotheses are leading theories of the
pathoetiology of schizophrenia, but they were developed in isolation. However, since they …
pathoetiology of schizophrenia, but they were developed in isolation. However, since they …
Dopamine and glutamate in schizophrenia: biology, symptoms and treatment
Glutamate and dopamine systems play distinct roles in terms of neuronal signalling, yet both
have been proposed to contribute significantly to the pathophysiology of schizophrenia. In …
have been proposed to contribute significantly to the pathophysiology of schizophrenia. In …
Overexpression of schizophrenia susceptibility factor human complement C4A promotes excessive synaptic loss and behavioral changes in mice
Abstract The complement component 4 (C4) gene is linked to schizophrenia and synaptic
refinement. In humans, greater expression of C4A in the brain is associated with an …
refinement. In humans, greater expression of C4A in the brain is associated with an …
The synaptic hypothesis of schizophrenia version III: a master mechanism
OD Howes, EC Onwordi - Molecular Psychiatry, 2023 - nature.com
The synaptic hypothesis of schizophrenia has been highly influential. However, new
approaches mean there has been a step-change in the evidence available, and some tenets …
approaches mean there has been a step-change in the evidence available, and some tenets …
Neuroimaging in schizophrenia: an overview of findings and their implications for synaptic changes
OD Howes, C Cummings, GE Chapman… - …, 2023 - nature.com
Over the last five decades, a large body of evidence has accrued for structural and metabolic
brain alterations in schizophrenia. Here we provide an overview of these findings, focusing …
brain alterations in schizophrenia. Here we provide an overview of these findings, focusing …
Economics and mental health: the current scenario
Economics and mental health are intertwined. Apart from the accumulating evidence of the
huge economic impacts of mental ill‐health, and the growing recognition of the effects that …
huge economic impacts of mental ill‐health, and the growing recognition of the effects that …
Assessment of noninvasive brain stimulation interventions for negative symptoms of schizophrenia: a systematic review and network meta-analysis
Importance Negative symptoms have a detrimental impact on functional outcomes and
quality of life in people with schizophrenia, and few therapeutic options are considered …
quality of life in people with schizophrenia, and few therapeutic options are considered …
Functional neuroimaging in psychiatry and the case for failing better
Psychiatric disorders encompass complex aberrations of cognition and affect and are
among the most debilitating and poorly understood of any medical condition. Current …
among the most debilitating and poorly understood of any medical condition. Current …
The clinical significance of duration of untreated psychosis: an umbrella review and random‐effects meta‐analysis
The idea that a longer duration of untreated psychosis (DUP) leads to poorer outcomes has
contributed to extensive changes in mental health services worldwide and has attracted …
contributed to extensive changes in mental health services worldwide and has attracted …