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Regulation of cholesterol homeostasis in health and diseases: from mechanisms to targeted therapeutics
Y Duan, K Gong, S Xu, F Zhang, X Meng… - Signal Transduction and …, 2022 - nature.com
Disturbed cholesterol homeostasis plays critical roles in the development of multiple
diseases, such as cardiovascular diseases (CVD), neurodegenerative diseases and …
diseases, such as cardiovascular diseases (CVD), neurodegenerative diseases and …
SARS-CoV-2 and innate immunity: the good, the bad, and the “goldilocks”
BL Sievers, MTK Cheng, K Csiba, B Meng… - Cellular & Molecular …, 2024 - nature.com
An ancient conflict between hosts and pathogens has driven the innate and adaptive arms of
immunity. Knowledge about this interplay can not only help us identify biological …
immunity. Knowledge about this interplay can not only help us identify biological …
Systemic and mucosal IgA responses are variably induced in response to SARS-CoV-2 mRNA vaccination and are associated with protection against subsequent …
S Sheikh-Mohamed, B Isho, GYC Chao, M Zuo… - Mucosal …, 2022 - nature.com
Although SARS-CoV-2 infects the upper respiratory tract, we know little about the amount,
type, and kinetics of antibodies (Ab) generated in the oral cavity in response to COVID-19 …
type, and kinetics of antibodies (Ab) generated in the oral cavity in response to COVID-19 …
Syncytia formation by SARS‐CoV‐2‐infected cells
J Buchrieser, J Dufloo, M Hubert, B Monel… - The EMBO …, 2020 - embopress.org
Severe cases of COVID‐19 are associated with extensive lung damage and the presence of
infected multinucleated syncytial pneumocytes. The viral and cellular mechanisms …
infected multinucleated syncytial pneumocytes. The viral and cellular mechanisms …
[HTML][HTML] Genetic screens identify host factors for SARS-CoV-2 and common cold coronaviruses
R Wang, CR Simoneau, J Kulsuptrakul, M Bouhaddou… - Cell, 2021 - cell.com
The Coronaviridae are a family of viruses that cause disease in humans ranging from mild
respiratory infection to potentially lethal acute respiratory distress syndrome. Finding host …
respiratory infection to potentially lethal acute respiratory distress syndrome. Finding host …
[HTML][HTML] Diabetes, obesity, metabolism, and SARS-CoV-2 infection: the end of the beginning
DJ Drucker - Cell metabolism, 2021 - cell.com
The increased prevalence of obesity, diabetes, and cardiovascular risk factors in people
hospitalized with severe COVID-19 illness has engendered considerable interest in the …
hospitalized with severe COVID-19 illness has engendered considerable interest in the …
SARS-CoV-2 requires acidic pH to infect cells
AJB Kreutzberger, A Sanyal, A Saminathan… - Proceedings of the …, 2022 - pnas.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cell entry starts with
membrane attachment and ends with spike (S) protein–catalyzed membrane fusion …
membrane attachment and ends with spike (S) protein–catalyzed membrane fusion …
The mechanism and consequences of SARS-CoV-2 spike-mediated fusion and syncytia formation
MM Rajah, A Bernier, J Buchrieser… - Journal of molecular …, 2022 - Elsevier
Syncytia are formed when individual cells fuse. SARS-CoV-2 induces syncytia when the
viral spike (S) protein on the surface of an infected cell interacts with receptors on …
viral spike (S) protein on the surface of an infected cell interacts with receptors on …
Opposing activities of IFITM proteins in SARS‐CoV‐2 infection
G Shi, AD Kenney, E Kudryashova, A Zani… - The EMBO …, 2021 - embopress.org
Interferon‐induced transmembrane proteins (IFITMs) restrict infections by many viruses, but
a subset of IFITMs enhance infections by specific coronaviruses through currently unknown …
a subset of IFITMs enhance infections by specific coronaviruses through currently unknown …
SARS-CoV-2 requires cholesterol for viral entry and pathological syncytia formation
DW Sanders, CC Jumper, PJ Ackerman, D Bracha… - elife, 2021 - elifesciences.org
Many enveloped viruses induce multinucleated cells (syncytia), reflective of membrane
fusion events caused by the same machinery that underlies viral entry. These syncytia are …
fusion events caused by the same machinery that underlies viral entry. These syncytia are …