Deciphering breast cancer: from biology to the clinic
Breast cancer remains a leading cause of cancer-related mortality in women, reflecting
profound disease heterogeneity, metastasis, and therapeutic resistance. Over the last …
profound disease heterogeneity, metastasis, and therapeutic resistance. Over the last …
Breast cancer—epidemiology, risk factors, classification, prognostic markers, and current treatment strategies—an updated review
Simple Summary Breast cancer is the most common cancer among women. It is estimated
that 2.3 million new cases of BC are diagnosed globally each year. Based on mRNA gene …
that 2.3 million new cases of BC are diagnosed globally each year. Based on mRNA gene …
Wnt signaling in breast cancer: biological mechanisms, challenges and opportunities
X Xu, M Zhang, F Xu, S Jiang - Molecular cancer, 2020 - Springer
Wnt signaling is a highly conserved signaling pathway that plays a critical role in controlling
embryonic and organ development, as well as cancer progression. Genome-wide …
embryonic and organ development, as well as cancer progression. Genome-wide …
Triple-negative breast cancer metastasis involves complex epithelial-mesenchymal transition dynamics and requires vimentin
Triple-negative breast cancer (TNBC) is an aggressive subtype associated with early
metastatic recurrence and worse patient outcomes. TNBC tumors express molecular …
metastatic recurrence and worse patient outcomes. TNBC tumors express molecular …
Selective glutamine metabolism inhibition in tumor cells improves antitumor T lymphocyte activity in triple-negative breast cancer
DN Edwards, VM Ngwa, AL Raybuck… - The Journal of …, 2021 - Am Soc Clin Investig
Rapidly proliferating tumor and immune cells need metabolic programs that support energy
and biomass production. The amino acid glutamine is consumed by effector T cells and …
and biomass production. The amino acid glutamine is consumed by effector T cells and …
Epithelial–mesenchymal transition in tumor metastasis
KT Yeung, J Yang - Molecular oncology, 2017 - Wiley Online Library
The epithelial–mesenchymal transition (EMT) is a developmental program that enables
stationary epithelial cells to gain the ability to migrate and invade as single cells. Tumor cells …
stationary epithelial cells to gain the ability to migrate and invade as single cells. Tumor cells …
The landscape of targeted therapies in TNBC
E Vagia, D Mahalingam, M Cristofanilli - Cancers, 2020 - mdpi.com
Triple negative breast cancer (TNBC) constitutes the most aggressive molecular subtype
among breast tumors. Despite progress on the underlying tumor biology, clinical outcomes …
among breast tumors. Despite progress on the underlying tumor biology, clinical outcomes …
Oncogenic lncRNA downregulates cancer cell antigen presentation and intrinsic tumor suppression
How tumor cells genetically lose antigenicity and evade immune checkpoints remains
largely elusive. We report that tissue-specific expression of the human long noncoding RNA …
largely elusive. We report that tissue-specific expression of the human long noncoding RNA …
Natural small molecules in breast cancer treatment: understandings from a therapeutic viewpoint
MR Islam, F Islam, MH Nafady, M Akter, S Mitra, R Das… - Molecules, 2022 - mdpi.com
Breast cancer (BrCa) is the most common malignancy in women and the second most
significant cause of death from cancer. BrCa is one of the most challenging malignancies to …
significant cause of death from cancer. BrCa is one of the most challenging malignancies to …
Comprehensive genomic analysis identifies novel subtypes and targets of triple-negative breast cancer
MD Burstein, A Tsimelzon, GM Poage… - Clinical Cancer …, 2015 - AACR
Purpose: Genomic profiling studies suggest that triple-negative breast cancer (TNBC) is a
heterogeneous disease. In this study, we sought to define TNBC subtypes and identify …
heterogeneous disease. In this study, we sought to define TNBC subtypes and identify …