A current challenge in cancer treatment is drug resistance. Even the most effective therapies
often fail to produce a complete and durable tumor response and ultimately give rise to …

BACKGROUND Despite many notable successes in prevention and control, infectious
diseases remain an enormous threat to human and animal health. The ecological and …

Ultrasound (US)‐mediated sonodynamic therapy (SDT) has the advantages of non‐
invasiveness and deep tissue penetration. Nanosystems are prominently used in …

Resistance of the Enterobacteriaceae to antibiotics, especially of the β lactam type, is
increasingly dominated by the mobilization of continuously expressed single genes that …

Populations that experience severe stress may avoid extinction through adaptation by
natural selection. This process is called evolutionary rescue and has been studied under …

The face of evolutionary biology is changing: from reconstructing and analysing the past to
predicting future evolutionary processes. Recent developments include prediction of …

Abstract Photothermal-chemotherapy (PT-CT) is a promising strategy for cancer treatment,
but its development is hindered by the issues regarding to the long-term safety of carriers …

The prevailing view that the evolution of cells in a tumor is driven by Darwinian selection has
never been rigorously tested. Because selection greatly affects the level of intratumor …

Antivirulence drugs are a new type of therapeutic drug that target virulence factors,
potentially revitalising the drug-development pipeline with new targets. As antivirulence …

Antibiotic resistance is 'bacteria changing in ways that reduce or eliminate the effectiveness
of antibiotics'[1]. These changes are due to bacterial evolution, and threaten the single …