[HTML][HTML] DNA methylation: a historical perspective
AL Mattei, N Bailly, A Meissner - Trends in Genetics, 2022 - cell.com
In 1925, 5-methylcytosine was first reported in bacteria. However, its biological importance
was not intuitive for several decades. After this initial lag, the ubiquitous presence of this …
was not intuitive for several decades. After this initial lag, the ubiquitous presence of this …
DNA methylation reprogramming during mammalian development
Y Zeng, T Chen - Genes, 2019 - mdpi.com
DNA methylation (5-methylcytosine, 5mC) is a major form of DNA modification in the
mammalian genome that plays critical roles in chromatin structure and gene expression. In …
mammalian genome that plays critical roles in chromatin structure and gene expression. In …
The interplay between DNA and histone methylation: molecular mechanisms and disease implications
Methylation of cytosine in CpG dinucleotides and histone lysine and arginine residues is a
chromatin modification that critically contributes to the regulation of genome integrity …
chromatin modification that critically contributes to the regulation of genome integrity …
[HTML][HTML] Navigating the DNA methylation landscape of cancer
A Nishiyama, M Nakanishi - Trends in Genetics, 2021 - cell.com
DNA methylation is a chemical modification that defines cell type and lineage through the
control of gene expression and genome stability. Disruption of DNA methylation control …
control of gene expression and genome stability. Disruption of DNA methylation control …
Staying true to yourself: mechanisms of DNA methylation maintenance in mammals
DNA methylation is essential to development and cellular physiology in mammals. Faulty
DNA methylation is frequently observed in human diseases like cancer and neurological …
DNA methylation is frequently observed in human diseases like cancer and neurological …
Methylation of DNA ligase 1 by G9a/GLP recruits UHRF1 to replicating DNA and regulates DNA methylation
L Ferry, A Fournier, T Tsusaka, G Adelmant, T Shimazu… - Molecular cell, 2017 - cell.com
DNA methylation is an essential epigenetic mark in mammals that has to be re-established
after each round of DNA replication. The protein UHRF1 is essential for this process; it has …
after each round of DNA replication. The protein UHRF1 is essential for this process; it has …
Allosteric control of mammalian DNA methyltransferases–a new regulatory paradigm
In mammals, DNA methylation is introduced by the DNMT1, DNMT3A and DNMT3B
methyltransferases, which are all large multi-domain proteins containing a catalytic C …
methyltransferases, which are all large multi-domain proteins containing a catalytic C …
Chromatin regulation through ubiquitin and ubiquitin-like histone modifications
Chromatin functions are influenced by the addition, removal, and recognition of histone post-
translational modifications (PTMs). Ubiquitin and ubiquitin-like (UBL) PTMs on histone …
translational modifications (PTMs). Ubiquitin and ubiquitin-like (UBL) PTMs on histone …
The Arabidopsis APOLO and human UPAT sequence-unrelated long noncoding RNAs can modulate DNA and histone methylation machineries in plants
C Fonouni-Farde, A Christ, T Blein, MF Legascue… - Genome Biology, 2022 - Springer
Abstract Background RNA-DNA hybrid (R-loop)-associated long noncoding RNAs
(lncRNAs), including the Arabidopsis lncRNA AUXIN-REGULATED PROMOTER LOOP …
(lncRNAs), including the Arabidopsis lncRNA AUXIN-REGULATED PROMOTER LOOP …
Structural basis of DNMT1 and DNMT3A-mediated DNA methylation
DNA methylation, one of the major epigenetic mechanisms, plays critical roles in regulating
gene expression, genomic stability and cell lineage commitment. The establishment and …
gene expression, genomic stability and cell lineage commitment. The establishment and …