[HTML][HTML] Characterization of dipyridamole as a novel ferroptosis inhibitor and its therapeutic potential in acute respiratory distress syndrome management
X Chen, J Shen, X Jiang, M Pan, S Chang, J Li… - …, 2024 - pmc.ncbi.nlm.nih.gov
Rationale: Ferroptosis in lung epithelium and endothelium contributes to the pathogenesis
of acute respiratory distress syndrome (ARDS), a critical and often fatal condition marked by …
of acute respiratory distress syndrome (ARDS), a critical and often fatal condition marked by …
Evidence for a lipofibroblast-to-Cthrc1+ myofibroblast reversible switch during the development and resolution of lung fibrosis in young mice
Background Fibrosis is often associated with aberrant repair mechanisms that ultimately
lead to organ failure. In the lung, idiopathic pulmonary fibrosis (IPF) is a fatal form of …
lead to organ failure. In the lung, idiopathic pulmonary fibrosis (IPF) is a fatal form of …
Fibroblast plasticity in pulmonary and cardiovascular fibrosis: Mechanistic insights and emerging therapeutic targets
Fibroblast plasticity plays a crucial role in the progression of fibrotic diseases, including
pulmonary fibrosis. Recent studies have investigated several models to understand the …
pulmonary fibrosis. Recent studies have investigated several models to understand the …
Exploring the Antifibrotic Potential of the heparan sulfate mimetic OTR4120: Insights from Preclinical Models
M Marega, N Mejdoubi-Charef, D Wiegard, MM Khan… - bioRxiv, 2024 - biorxiv.org
Rationale: Idiopathic pulmonary fibrosis (IPF) is a debilitating lung disease characterized by
excessive deposition of extracellular matrix (ECM), resulting in lung function impairment …
excessive deposition of extracellular matrix (ECM), resulting in lung function impairment …