[HTML][HTML] Aldehyde dehydrogenase 1A1 in stem cells and cancer
H Tomita, K Tanaka, T Tanaka, A Hara - Oncotarget, 2016 - ncbi.nlm.nih.gov
The human genome contains 19 putatively functional aldehyde dehydrogenase (ALDH)
genes, which encode enzymes critical for detoxification of endogenous and exogenous …
genes, which encode enzymes critical for detoxification of endogenous and exogenous …
Inflammation, vitamin B6 and related pathways
PM Ueland, A McCann, Ø Midttun, A Ulvik - Molecular aspects of medicine, 2017 - Elsevier
The active form of vitamin B6, pyridoxal 5′-phosphate (PLP), serves as a co-factor in more
than 150 enzymatic reactions. Plasma PLP has consistently been shown to be low in …
than 150 enzymatic reactions. Plasma PLP has consistently been shown to be low in …
Insights into aldehyde dehydrogenase enzymes: a structural perspective
Aldehyde dehydrogenases engage in many cellular functions, however their dysfunction
resulting in accumulation of their substrates can be cytotoxic. ALDHs are responsible for the …
resulting in accumulation of their substrates can be cytotoxic. ALDHs are responsible for the …
Aldehyde dehydrogenase inhibitors: a comprehensive review of the pharmacology, mechanism of action, substrate specificity, and clinical application
V Koppaka, DC Thompson, Y Chen, M Ellermann… - Pharmacological …, 2012 - Elsevier
Aldehyde dehydrogenases (ALDHs) belong to a superfamily of enzymes that play a key role
in the metabolism of aldehydes of both endogenous and exogenous derivation. The human …
in the metabolism of aldehydes of both endogenous and exogenous derivation. The human …
Drug-tolerant persister cells in cancer therapy resistance
PK Dhanyamraju, TD Schell, S Amin, GP Robertson - Cancer research, 2022 - AACR
One of the current stumbling blocks in our fight against cancer is the development of
acquired resistance to therapy, which is attributable to approximately 90% of cancer-related …
acquired resistance to therapy, which is attributable to approximately 90% of cancer-related …
The role of human aldehyde dehydrogenase in normal and cancer stem cells
Normal stem cells and cancer stem cells (CSCs) share similar properties, in that both have
the capacity to self-renew and differentiate into multiple cell types. In both the normal stem …
the capacity to self-renew and differentiate into multiple cell types. In both the normal stem …
Non-P450 aldehyde oxidizing enzymes: the aldehyde dehydrogenase superfamily
SA Marchitti, C Brocker, D Stagos… - Expert opinion on drug …, 2008 - Taylor & Francis
Background: Aldehydes are highly reactive molecules. While several non-P450 enzyme
systems participate in their metabolism, one of the most important is the aldehyde …
systems participate in their metabolism, one of the most important is the aldehyde …
The power to reduce: pyridine nucleotides–small molecules with a multitude of functions
N Pollak, C Dölle, M Ziegler - Biochemical Journal, 2007 - portlandpress.com
The pyridine nucleotides NAD and NADP play vital roles in metabolic conversions as signal
transducers and in cellular defence systems. Both coenzymes participate as electron …
transducers and in cellular defence systems. Both coenzymes participate as electron …
[HTML][HTML] Aldehyde dehydrogenases in cancer stem cells: potential as therapeutic targets
DW Clark, K Palle - Annals of translational medicine, 2016 - ncbi.nlm.nih.gov
Resistance to current chemotherapeutic or radiation-based cancer treatment strategies is a
serious concern. Cancer stem cells (CSCs) are typically able to evade treatment and …
serious concern. Cancer stem cells (CSCs) are typically able to evade treatment and …
Aldehyde toxicity and metabolism: the role of aldehyde dehydrogenases in detoxification, drug resistance and carcinogenesis
Aldehydes are carbonyl compounds found ubiquitously in the environment, derived from
both natural and anthropogenic sources. As the aldehydes are reactive species, therefore …
both natural and anthropogenic sources. As the aldehydes are reactive species, therefore …