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The advancement and application of the single-cell transcriptome in biological and medical research
K Huang, Y Xu, T Feng, H Lan, F Ling, H **ang, Q Liu - Biology, 2024 - mdpi.com
Simple Summary Single-cell RNA sequencing (scRNA-seq) is a technique that identifies
different types of cells in a tissue and reveals how individual cells express genes. This …
different types of cells in a tissue and reveals how individual cells express genes. This …
[HTML][HTML] The repeated bout effect evokes the training-induced skeletal muscle cellular memory
M Calvo-Rubio, E Garcia-Domiguez… - Free Radical Biology …, 2024 - Elsevier
Physical exercise is well-established as beneficial for health. With the 20th-century
epidemiological transition, promoting healthy habits like exercise has become crucial for …
epidemiological transition, promoting healthy habits like exercise has become crucial for …
[HTML][HTML] Novel drug targets and molecular mechanisms for sarcopenia based on systems biology
Sarcopenia is a major public health concern among older adults, leading to disabilities, falls,
fractures, and mortality. This study aimed to elucidate the pathophysiological mechanisms of …
fractures, and mortality. This study aimed to elucidate the pathophysiological mechanisms of …
The Myotendinous Junction—Form and Function
AL Mackey - Cold Spring Harbor perspectives in biology, 2024 - cshperspectives.cshlp.org
A critical link in the chain of force transmission from muscle fiber cross-bridge to bone is the
interface between muscle and tendon—the myotendinous junction (MTJ). To meet the …
interface between muscle and tendon—the myotendinous junction (MTJ). To meet the …
Nutrition in the prevention and treatment of skeletal muscle ageing and sarcopenia: A single nutrient, a whole food and a whole diet approach
Loss of skeletal muscle strength and mass (sarcopenia) is common in older adults and
associated with an increased risk of disability, frailty and premature death. Finding cost …
associated with an increased risk of disability, frailty and premature death. Finding cost …
[HTML][HTML] Acute Sarcopenia: Mechanisms and Management
Background: Acute sarcopenia refers to the swift decline in muscle function and mass
following acute events such as illness, surgery, trauma, or burns that presents significant …
following acute events such as illness, surgery, trauma, or burns that presents significant …
Investigation of human aging at the single-cell level
Y Li, Q Wang, Y Xuan, J Zhao, J Li, Y Tian… - Ageing Research …, 2024 - Elsevier
Human aging is characterized by a gradual decline in physiological functions and an
increased susceptibility to various diseases. The complex mechanisms underlying human …
increased susceptibility to various diseases. The complex mechanisms underlying human …
Molecular mechanisms and potential interventions during aging-associated sarcopenia
X Luo, J Wang, Q Ju, T Li, X Bi - Mechanisms of Ageing and Development, 2025 - Elsevier
Sarcopenia, a common condition observed in the elderly, presenting a significant public
health challenge due to its high prevalence, insidious onset and diverse systemic effects …
health challenge due to its high prevalence, insidious onset and diverse systemic effects …
Transcription factor networks in cellular quiescence
M Mitra, SL Batista, HA Coller - Nature Cell Biology, 2025 - nature.com
Many of the cells in mammalian tissues are in a reversible quiescent state; they are not
dividing, but retain the ability to proliferate in response to extracellular signals. Quiescence …
dividing, but retain the ability to proliferate in response to extracellular signals. Quiescence …
Cellular deconstruction of the human skeletal muscle microenvironment identifies an exercise-induced histaminergic crosstalk
Plasticity of skeletal muscle is induced by transcriptional and translational events in
response to exercise, leading to multiple health and performance benefits. The skeletal …
response to exercise, leading to multiple health and performance benefits. The skeletal …