The advancement and application of the single-cell transcriptome in biological and medical research

K Huang, Y Xu, T Feng, H Lan, F Ling, H **ang, Q Liu - Biology, 2024 - mdpi.com
Simple Summary Single-cell RNA sequencing (scRNA-seq) is a technique that identifies
different types of cells in a tissue and reveals how individual cells express genes. This …

[HTML][HTML] The repeated bout effect evokes the training-induced skeletal muscle cellular memory

M Calvo-Rubio, E Garcia-Domiguez… - Free Radical Biology …, 2024 - Elsevier
Physical exercise is well-established as beneficial for health. With the 20th-century
epidemiological transition, promoting healthy habits like exercise has become crucial for …

[HTML][HTML] Novel drug targets and molecular mechanisms for sarcopenia based on systems biology

AB Ceyhan, M Ozcan, W Kim, X Li, O Altay… - Biomedicine & …, 2024 - Elsevier
Sarcopenia is a major public health concern among older adults, leading to disabilities, falls,
fractures, and mortality. This study aimed to elucidate the pathophysiological mechanisms of …

The Myotendinous Junction—Form and Function

AL Mackey - Cold Spring Harbor perspectives in biology, 2024 - cshperspectives.cshlp.org
A critical link in the chain of force transmission from muscle fiber cross-bridge to bone is the
interface between muscle and tendon—the myotendinous junction (MTJ). To meet the …

Nutrition in the prevention and treatment of skeletal muscle ageing and sarcopenia: A single nutrient, a whole food and a whole diet approach

A Granic, AA Sayer, R Cooper… - Proceedings of the …, 2024 - cambridge.org
Loss of skeletal muscle strength and mass (sarcopenia) is common in older adults and
associated with an increased risk of disability, frailty and premature death. Finding cost …

[HTML][HTML] Acute Sarcopenia: Mechanisms and Management

S Damanti, E Senini, R De Lorenzo, A Merolla… - Nutrients, 2024 - mdpi.com
Background: Acute sarcopenia refers to the swift decline in muscle function and mass
following acute events such as illness, surgery, trauma, or burns that presents significant …

Investigation of human aging at the single-cell level

Y Li, Q Wang, Y Xuan, J Zhao, J Li, Y Tian… - Ageing Research …, 2024 - Elsevier
Human aging is characterized by a gradual decline in physiological functions and an
increased susceptibility to various diseases. The complex mechanisms underlying human …

Molecular mechanisms and potential interventions during aging-associated sarcopenia

X Luo, J Wang, Q Ju, T Li, X Bi - Mechanisms of Ageing and Development, 2025 - Elsevier
Sarcopenia, a common condition observed in the elderly, presenting a significant public
health challenge due to its high prevalence, insidious onset and diverse systemic effects …

Transcription factor networks in cellular quiescence

M Mitra, SL Batista, HA Coller - Nature Cell Biology, 2025 - nature.com
Many of the cells in mammalian tissues are in a reversible quiescent state; they are not
dividing, but retain the ability to proliferate in response to extracellular signals. Quiescence …

Cellular deconstruction of the human skeletal muscle microenvironment identifies an exercise-induced histaminergic crosstalk

T Van der Stede, A Van de Loock, G Turiel, C Hansen… - Cell Metabolism, 2025 - cell.com
Plasticity of skeletal muscle is induced by transcriptional and translational events in
response to exercise, leading to multiple health and performance benefits. The skeletal …