Physical exercise is well-established as beneficial for health. With the 20th-century
epidemiological transition, promoting healthy habits like exercise has become crucial for …

Loss of skeletal muscle strength and mass (sarcopenia) is common in older adults and
associated with an increased risk of disability, frailty and premature death. Finding cost …

A critical link in the chain of force transmission from muscle fiber cross-bridge to bone is the
interface between muscle and tendon—the myotendinous junction (MTJ). To meet the …

Background: Acute sarcopenia refers to the swift decline in muscle function and mass
following acute events such as illness, surgery, trauma, or burns that presents significant …

Many of the cells in mammalian tissues are in a reversible quiescent state; they are not
dividing, but retain the ability to proliferate in response to extracellular signals. Quiescence …

Adult stem cells maintain homeostasis and enable regeneration of most tissues.
Quiescence, proliferation, and differentiation of stem cells and their progenitors are tightly …

Calorie restriction (CR) and treatment with rapamycin (RM), an inhibitor of the mTORC1
growth-promoting signaling pathway, are known to slow aging and promote health from …

Human aging is characterized by a gradual decline in physiological functions and an
increased susceptibility to various diseases. The complex mechanisms underlying human …

Sarcopenia is a major public health concern among older adults, leading to disabilities, falls,
fractures, and mortality. This study aimed to elucidate the pathophysiological mechanisms of …

Sarcopenia, a common condition observed in the elderly, presenting a significant public
health challenge due to its high prevalence, insidious onset and diverse systemic effects …