The brain lacks a classic lymphatic drainage system. How it is cleansed of damaged
proteins, cellular debris, and molecular by-products has remained a mystery for decades …

Abstract Calcium ion (Ca 2+) dysregulation is one of the main causes of neuronal cell death
and brain damage after cerebral ischemia. During ischemic stroke, the ability of neurons to …

The endoplasmic reticulum (ER) is crucial for protein quality control, and disruptions in its
function can lead to various diseases. ER stress triggers an adaptive response called the …

Endoplasmic reticulum (ER) and mitochondria are two important organelles that are highly
dynamic in mammalian cells. The physical connection between them is mitochondria …

Cerebral ischemia-reperfusion (CIR) injury is initiated by the generation of reactive oxygen
species (ROS), which leads to the oxidation of cellular proteins, DNA, and lipids as an initial …

Efficient cell‐to‐cell communication is essential for tissue development, homeostasis, and
the maintenance of cellular functions after injury. Tunneling nanotubes (TNTs) have …

Objectives Dysfunction in mitochondrial activity may have profound role in ischemic stroke-
induced neuronal death, hence maintaining the mitochondrial function seems to be valuable …

Ischemic stroke (IS) is a neurological disorder prevalent worldwide with a high disability and
mortality rate. In the clinic setting, tissue plasminogen activator (tPA) and thrombectomy …

Statins have evident neuroprotective role in acute ischemic stroke (AIS). The pleiotropic
effect by which statin exerts neuroprotective effects, needs to be explored for considering it …

Simple Summary Metabolic reprogramming is required for both malignant transformation
and tumor development, including invasion and metastasis. Melatonin (5-methoxy-N …