Neurodevelopmental diseases (NDDs), such as autism spectrum disorders, epilepsy, and
schizophrenia, are characterized by diverse facets of neurological and psychiatric …

Post-translational modification (PTM) is an essential mechanism for enhancing the
functional diversity of proteins and adjusting their signaling networks. The reversible …

Angelman syndrome (AS), an early-onset neurodevelopmental disorder characterized by
abnormal gait, intellectual disabilities, and seizures, occurs when the maternal allele of the …

The ubiquitin proteasome system (UPS) is a proteolytic machinery for the degradation of
protein substrates that are post-translationally conjugated with ubiquitin polymers through …

Over thirty years have passed since the first description of ubiquitin-positive structures in the
brain of patients suffering from Alzheimer's disease. Meanwhile, the intracellular …

Abstract Na+/K+-ATPase is a transmembrane protein that has important roles in the
maintenance of electrochemical gradients across cell membranes by transporting three Na+ …

Angelman syndrome (AS) is a rare neurodevelopmental disease that is caused by the loss
of function of the maternal copy of ubiquitin–protein ligase E3A (UBE3A) on the …

Autism spectrum disorders (ASDs) are complex neurodevelopmental conditions
characterized by deficits in social interaction and communication, as well as repetitive …

Reprogramming of somatic cells into induced Pluripotent Stem Cells (iPSCs) is a major leap
towards personalised approaches to disease modelling and cell-replacement therapies …

Angelman syndrome (AS) is a rare genetic neurodevelopmental disorder caused by the
maternally inherited loss of function of the UBE3A gene. AS is characterized by a …