Vesicular/membrane trafficking essentially regulates the compartmentalization and
abundance of proteins within the cells and contributes in many signalling pathways. This …

Our understanding of the plasma membrane, once viewed simply as a static barrier, has
been revolutionized to encompass a complex, dynamic organelle that integrates the cell with …

Pontin (RUVBL1, TIP49, TIP49a, Rvb1) and Reptin (RUVBL2, TIP48, TIP49b, Rvb2) are
highly conserved ATPases of the AAA+ (ATPases Associated with various cellular Activities) …

Agola JO, Jim PA, Ward HH, BasuRay S, Wandinger‐Ness A. Rab GTPases as regulators of
endocytosis, targets of disease and therapeutic opportunities. Rab GTPases are well …

Initially discovered as an estrogen-responsive gene in breast cancer cell lines, anterior
gradient 2 (AGR2) is a developmentally regulated gene belonging to the protein disulfide …

Endocytosis participates in downregulating incoming signals, but 'signaling endosomes'
may also serve as physical platforms for crosstalk between signaling pathways. Here, we …

Reptin and Pontin belong to the family of AAA+ ATPases (ATPases Associated with various
cellular Activities). Several studies have reported their overexpression in cancer, including …

Endocytosis allows cargo to enter a series of specialized endosomal compartments,
beginning with early endosomes harboring Rab5 and its effector EEA1. There are, however …

Endosomal adaptor proteins are important regulators of signaling pathways underlying
many biological processes. These adaptors can integrate signals from multiple pathways via …

APPLs (adaptor proteins containing the pleckstrin homology domain, phosphotyrosine
binding domain and leucine zipper motif) are multifunctional adaptor proteins that bind to …