Exploring the past and the future of protein evolution with ancestral sequence reconstruction: the 'retro'approach to protein engineering
Y Gumulya, EMJ Gillam - Biochemical Journal, 2017 - portlandpress.com
A central goal in molecular evolution is to understand the ways in which genes and proteins
evolve in response to changing environments. In the absence of intact DNA from fossils …
evolve in response to changing environments. In the absence of intact DNA from fossils …
Forensic genetics and genomics: Much more than just a human affair
While traditional forensic genetics has been oriented towards using human DNA in criminal
investigation and civil court cases, it currently presents a much wider application range …
investigation and civil court cases, it currently presents a much wider application range …
PhylomeDB v4: zooming into the plurality of evolutionary histories of a genome
J Huerta-Cepas, S Capella-Gutierrez… - Nucleic acids …, 2014 - academic.oup.com
Phylogenetic trees representing the evolutionary relationships of homologous genes are the
entry point for many evolutionary analyses. For instance, the use of a phylogenetic tree can …
entry point for many evolutionary analyses. For instance, the use of a phylogenetic tree can …
M1CR0B1AL1Z3R—a user-friendly web server for the analysis of large-scale microbial genomics data
O Avram, D Rapoport, S Portugez… - Nucleic acids …, 2019 - academic.oup.com
Large-scale mining and analysis of bacterial datasets contribute to the comprehensive
characterization of complex microbial dynamics within a microbiome and among different …
characterization of complex microbial dynamics within a microbiome and among different …
Tangled up in two: a burst of genome duplications at the end of the Cretaceous and the consequences for plant evolution
K Vanneste, S Maere… - … Transactions of the …, 2014 - royalsocietypublishing.org
Genome sequencing has demonstrated that besides frequent small-scale duplications, large-
scale duplication events such as whole genome duplications (WGDs) are found on many …
scale duplication events such as whole genome duplications (WGDs) are found on many …
An investigation of irreproducibility in maximum likelihood phylogenetic inference
Phylogenetic trees are essential for studying biology, but their reproducibility under identical
parameter settings remains unexplored. Here, we find that 3515 (18.11%) IQ-TREE-inferred …
parameter settings remains unexplored. Here, we find that 3515 (18.11%) IQ-TREE-inferred …
Dissecting incongruence between concatenation-and quartet-based approaches in phylogenomic data
Topological conflict or incongruence is widespread in phylogenomic data. Concatenation-
and coalescent-based approaches often result in incongruent topologies, but the causes of …
and coalescent-based approaches often result in incongruent topologies, but the causes of …
High-throughput sequencing (HTS) for the analysis of viral populations
Abstract The development of High-Throughput Sequencing (HTS) technologies is having a
major impact on the genomic analysis of viral populations. Current HTS platforms can …
major impact on the genomic analysis of viral populations. Current HTS platforms can …
Phylogenomic systematics of ostariophysan fishes: ultraconserved elements support the surprising non-monophyly of characiformes
Ostariophysi is a superorder of bony fishes including more than 10,300 species in 1100
genera and 70 families. This superorder is traditionally divided into five major groups …
genera and 70 families. This superorder is traditionally divided into five major groups …
The evolution of functional complexity within the β-amylase gene family in land plants
Abstract Background β-Amylases (BAMs) are a multigene family of glucan hydrolytic
enzymes playing a key role not only for plant biology but also for many industrial …
enzymes playing a key role not only for plant biology but also for many industrial …