Myokines are molecules produced and secreted by skeletal muscle to act in an auto‐, para‐
and endocrine manner to alter physiological function of target tissues. The growing number …

Menopause is an age-dependent physiological condition associated with a natural decline
in oestrogen levels, which causes a progressive decrease of muscle mass and strength and …

For centuries, regular exercise has been acknowledged as a potent stimulus to promote,
maintain, and restore healthy functioning of nearly every physiological system of the human …

Denervation of skeletal muscles induces severe muscle atrophy, which is preceded by
cellular alterations such as increased plasma membrane permeability, reduced resting …

Osteoporosis and sarcopenia are age-related musculoskeletal pathologies that often
develop in parallel. Osteoporosis is characterized by a reduced bone mass and an …

Aging and sedentary life style are considered independent risk factors for many disorders.
Under these conditions, accumulation of dysfunctional and damaged cellular proteins and …

Exercise training promotes physical and bone health, and is the first choice of non-drug
strategies that help to improve the prognosis and complications of many chronic diseases …

Both sarcopenia and osteoporosis are common geriatric diseases causing huge
socioeconomic burdens, and clinically, they often occur simultaneously. Observational …

Neuromuscular impairment and reduced musculoskeletal integrity are hallmarks of spinal
cord injury (SCI) that hinder locomotor recovery. These impairments are precipitated by the …

Osteoarthritis is the most common form of arthritis and is a substantial burden for patients
with the disease. Currently, there is no cure for osteoarthritis, but many emerging therapies …