The discovery of novel small-molecule antibacterial drugs has been stalled for many years.
The purpose of this review is to underscore and illustrate those scientific problems unique to …

In recent years, even with remarkable scientific advancements and a significant increase of
global research and development spending, drugs are frequently withdrawn from markets …

Here off-target binding implies the binding of a small molecule of therapeutic interest to a
protein target other than the primary target for which it was intended. Increasingly such off …

Polypharmacology-based strategies are gaining increased attention as a novel approach to
obtaining potentially innovative medicines for multifactorial diseases. However, some within …

Target-based screening is one of the major approaches in drug discovery. Besides the
intended target, unexpected drug off-target interactions often occur, and many of them have …

Ligand profiling is an emerging computational method for predicting the most likely targets of
a bioactive compound and therefore anticipating adverse reactions, side effects and drug …