• The specific situation of the patient. Unless otherwise provided for by national regulations,
off-label use of medication should be limited to situations where it is in the patient's interest …

Aims This report from the European Society of Cardiology (ESC) Atlas Project updates and
expands upon the widely cited 2019 report in presenting cardiovascular disease (CVD) …

The activation of stress-related neuroendocrine systems helps to maintain homeostasis, but
excessive stress can damage body functions. We review current evidence from basic …

Executive summary The Lancet Countdown is an international collaboration that
independently monitors the health consequences of a changing climate. Publishing …

Background Racial and ethnic disparities in mortality persist in the US population. We
studied the contribution of social determinants of health (SDoH) to racial and ethnic …

Executive summary 2020 will go down in history as the year when the global community was
awakened to the fragility of human health and the interdependence of the ecosystem …

Stroke is the second leading cause of death and the third leading cause of disability
worldwide. Though the burden of stroke worldwide seems to have declined in the past three …

Objective The increased reliance on digital technologies to deliver healthcare as a result of
the COVID-19 pandemic has meant pre-existing disparities in digital access and utilisation …

Depression is one of the most common comorbidities of many chronic medical diseases
including cancer and cardiovascular, metabolic, inflammatory and neurological disorders …

As global deaths from COVID-19 continue to rise, the world's governments, institutions, and
agencies are still working toward an understanding of who is most at risk of death. In this …