The longevity of some of the behavioral abnormalities that characterize drug addiction has
suggested that regulation of neural gene expression may be involved in the process by …

Acute exposure to cocaine transiently induces several Fos family transcription factors in the
nucleus accumbens, a region of the brain that is important for addiction,. In contrast, chronic …

Regulation of gene expression is considered a plausible mechanism of drug addiction,
given the stability of behavioural abnormalities that define an addicted state. Among many …

The mechanism of action of electroconvulsive seizures (ECS), one of the most effective
treatments of major depression, may involve the regulation of gene expression. Chromatin …

ΔFosB is a unique transcription factor that plays an essential role in long-term adaptive
changes in the brain associated with diverse conditions, such as drug addiction, Parkinson's …

Acute and chronic stress differentially regulate immediate-early gene (IEG) expression in the
brain. Although acute stress induces c-Fos and FosB, repeated exposure to stress …

ΔFosB is a member of the Fos family of transcription factors. While other family members are
induced rapidly but transiently in response to a host of acute stimuli, ΔFosB is unique in that …

ΔFosB, a member of the Fos family of transcription factors, is derived from the fosB gene via
alternative splicing. Just as c-Fos and many other Fos family members are induced rapidly …

Δ FosB is a transcription factor that accumulates in a region-specific manner in the brain
after chronic perturbations. For example, repeated administration of drugs of abuse …

NMDA receptor-mediated calcium transients play a critical role in synaptogenesis, synaptic
plasticity, and excitotoxicity. NMDA receptors are heteromeric complexes of NR1A combined …