The osteosarcoma microenvironment: a complex but targetable ecosystem
Osteosarcomas are the most frequent primary bone sarcomas, affecting mainly children,
adolescents, and young adults, and with a second peak of incidence in elderly individuals …
adolescents, and young adults, and with a second peak of incidence in elderly individuals …
Sarcoma treatment in the era of molecular medicine
Sarcomas are heterogeneous and clinically challenging soft tissue and bone cancers.
Although constituting only 1% of all human malignancies, sarcomas represent the second …
Although constituting only 1% of all human malignancies, sarcomas represent the second …
Targeting molecular mechanisms underlying treatment efficacy and resistance in osteosarcoma: a review of current and future strategies
I Lilienthal, N Herold - International journal of molecular sciences, 2020 - mdpi.com
Osteosarcoma is the most common primary malignant bone tumour in children and
adolescents. Due to micrometastatic spread, radical surgery alone rarely results in cure …
adolescents. Due to micrometastatic spread, radical surgery alone rarely results in cure …
Immune infiltration and PD-L1 expression in the tumor microenvironment are prognostic in osteosarcoma
Osteosarcoma patient survival has remained stagnant for 30 years. Novel therapeutic
approaches are needed to improve outcomes. We examined the expression of Programmed …
approaches are needed to improve outcomes. We examined the expression of Programmed …
The contribution of immune infiltrates and the local microenvironment in the pathogenesis of osteosarcoma
Osteosarcoma is a rare primary bone cancer characterized by cancer cells producing
calcified osteoid extracellular matrix and inducing lung metastases with a high frequency …
calcified osteoid extracellular matrix and inducing lung metastases with a high frequency …
Acidity‐Triggered Transformable Polypeptide Self‐Assembly to Initiate Tumor‐Specific Biomineralization
Y Liu, Z Jiang, S Tong, Y Sun, Y Zhang… - Advanced …, 2023 - Wiley Online Library
Biomineralization is a normal physiological process that includes nucleation, crystal growth,
phase transformation, and orientation evolution. Notably, artificially induced …
phase transformation, and orientation evolution. Notably, artificially induced …
Scaffold-based 3D cellular models mimicking the heterogeneity of osteosarcoma stem cell niche
The failure of the osteosarcoma conventional therapies leads to the growing need for novel
therapeutic strategies. The lack of specificity for the Cancer Stem Cells (CSCs) population …
therapeutic strategies. The lack of specificity for the Cancer Stem Cells (CSCs) population …
Energy metabolism in osteoclast formation and activity
Osteoclastogenesis and osteolysis are energy-consuming processes supported by high
metabolic activities. In human osteoclasts derived from the fusion of monocytic precursors …
metabolic activities. In human osteoclasts derived from the fusion of monocytic precursors …
The role of tumor-associated macrophages in osteosarcoma progression–therapeutic implications
Q Huang, X Liang, T Ren, Y Huang, H Zhang, Y Yu… - Cellular Oncology, 2021 - Springer
Background Osteosarcoma (OS) is the most common primary malignant bone tumor.
Compared with previous treatment modalities, such as amputation, more recent …
Compared with previous treatment modalities, such as amputation, more recent …
Bone microenvironment signals in osteosarcoma development
A Alfranca, L Martinez-Cruzado, J Tornin… - Cellular and Molecular …, 2015 - Springer
The bone is a complex connective tissue composed of many different cell types such as
osteoblasts, osteoclasts, chondrocytes, mesenchymal stem/progenitor cells, hematopoietic …
osteoblasts, osteoclasts, chondrocytes, mesenchymal stem/progenitor cells, hematopoietic …