In mammals, hundreds of proteins use iron in a multitude of cellular functions, including vital
processes such as mitochondrial respiration, gene regulation and DNA synthesis or repair …

In vertebrates, transferrin (Tf) safely delivers iron through circulation to cells. Tf-bound iron is
incorporated through Tf receptor (TfR) 1-mediated endocytosis. TfR1 can mediate cellular …

Develo** vehicles that efficiently deliver genes throughout the human central nervous
system (CNS) will broaden the range of treatable genetic diseases. We engineered an …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has been
detected in almost all organs of coronavirus disease-19 patients, although some organs do …

CVB3 is a single positive-strand enterovirus, and a common pathogen in myocarditis
etiology. Although a number of antiviral candidates are under development, specific targeted …

Over the past few years, several groups have identified new genes that are transcriptionally
induced downstream of type I interferon (IFN) signalling and that inhibit infection by …

Purpose of the review The ongoing outbreak of novel coronavirus pneumonia (COVID-19)
caused by the 2019 novel coronavirus (SARS-CoV-2) in China is lifting widespread …

INTRODUCTION Most studies of human genetic variation have focused on single-nucleotide
variants (SNVs). However, copy-number variants (CNVs) affect more base pairs of DNA …

Abstract The transferrin receptor (TfR1), which mediates cellular iron uptake through clathrin-
dependent endocytosis of iron-loaded transferrin, plays a key role in iron homeostasis …

Alphaviruses, like many other arthropod-borne viruses, infect vertebrate species and insect
vectors separated by hundreds of millions of years of evolutionary history. Entry into …