The mitochondrial electron transport chain utilizes a series of electron transfer reactions to
generate cellular ATP through oxidative phosphorylation. A consequence of electron …

In this last decade, a deeper understanding of the pathophysiology of hereditary red cell
disorders and the development of novel classes of pharmacologic agents have provided …

Sickle cell disease (SCD) is a chronic hemolytic and systemic hypoxia condition with
constant oxidative stress and significant metabolic alterations. However, little is known about …

Sickle cell disease (SCD) is the most severe monogenic hemoglobinopathy caused by a
single genetic mutation that leads to repeated polymerization and depolymerization of …

β-thalassemia and sickle cell disease (SCD) are inherited hemoglobinopathies that result in
both quantitative and qualitative variations in the β-globin chain. These in turn lead to …

Low arginine bioavailability is associated with vaso‐occlusive painful crisis (VOC) severity in
sickle cell anemia (SCA) and predicts need for pediatric hospitalization. Intravenous …

Rationale: Acute changes in cardiopulmonary hemodynamics that include tricuspid
regurgitant jet velocity (TRV) elevation measured by Doppler echocardiography are often …

Erythroid cells undergo a highly complex maturation process, resulting in dynamic changes
that generate red blood cells (RBCs) highly rich in haemoglobin. The end stages of the …

Sickle cell disease is an inherited blood disorder afflicting an estimated 100,000 individuals
in the United States and over 20 million people worldwide. The disease is heralded as the …

Postoperative atrial fibrillation (POAF) is a common complication of coronary artery bypass
grafting (CABG) procedures. However, the molecular mechanism of POAF remains poorly …