CRISPR–Cas is a widespread adaptive immune system in bacteria and archaea that
protects against viral infection by targeting specific invading nucleic acid sequences …

Advances in our understanding of prokaryotic antiphage defense mechanisms in the past
few years have revealed a multitude of new cyclic nucleotide signaling molecules that play a …

Two prokaryotic defence systems, prokaryotic Argonautes (pAgos) and CRISPR–Cas, detect
and cleave invader nucleic acids using complementary guides and the nuclease activities of …

The principal biological function of bacterial and archaeal CRISPR systems is RNA-guided
adaptive immunity against viruses and other mobile genetic elements (MGEs). These …

Abstract Type III CRISPR-Cas loci encode some of the most abundant, yet complex, immune
systems of prokaryotes. They are composed of a Cas10 complex that uses an RNA guide to …

Abstract Prokaryotic type III CRISPR–Cas systems provide immunity against viruses and
plasmids using CRISPR-associated Rossman fold (CARF) protein effectors,,,–. Recognition …

Argonaute proteins (Agos) bind short nucleic acids as guides and are directed by them to
recognize target complementary nucleic acids. Diverse prokaryotic Agos (pAgos) play …

Type III CRISPR systems detect invading RNA, resulting in the activation of the enzymatic
Cas10 subunit. The Cas10 cyclase domain generates cyclic oligoadenylate (cOA) second …

CRISPR-Cas provides adaptive immunity in prokaryotes. Type III CRISPR systems detect
invading RNA and activate the catalytic Cas10 subunit, which generates a range of …

Type III CRISPR systems synthesize cyclic oligoadenylate (cOA) second messengers as part
of a multi-faceted immune response against invading mobile genetic elements (MGEs). cOA …