Cytokine storm syndrome (CSS) has generally been described as a collection of clinical
manifestations resulting from an overactivated immune system. Cytokine storms (CSs) are …

Receptor-interacting serine/threonine-protein kinase 1 (RIPK1) is a key mediator of cell
death and inflammation. The unique hydrophobic pocket in the allosteric regulatory domain …

Summary Systemic Lupus Erythematosus (SLE) is characterized by B cells lacking IgD and
CD27 (double negative; DN). We show that DN cell expansions reflected a subset of CXCR5 …

Cells must adapt to changes in their environment to maintain cell, tissue and organismal
integrity in the face of mechanical, chemical or microbiological stress. Nuclear factor-κB (NF …

Systemic autoinflammatory diseases are driven by abnormal activation of innate immunity.
Herein we describe a new disease caused by high-penetrance heterozygous germline …

Growing up on a dairy farm protects children from allergy, hay fever, and asthma. A
mechanism linking exposure to this endotoxin (bacterial lipopolysaccharide)–rich …

Although known for many years as a nuclear factor (NF)-κB inhibitory and antiapoptotic
signaling protein, A20 has recently attracted much attention because of its ubiquitin …

Although the histological changes seen in psoriasis have long been well characterized, the
underlying cellular and molecular mechanisms have only begun to be elucidated over the …

Psoriasis is a common immune-mediated disorder that affects the skin, nails and joints. To
identify psoriasis susceptibility loci, we genotyped 438,670 SNPs in 1,409 psoriasis cases …

A20 (also known as TNFAIP3) is a potent anti-inflammatory signalling molecule that restricts
multiple intracellular signalling cascades. Recent studies in three general areas have …