LAG-3, TIM-3, and TIGIT: Distinct functions in immune regulation

N Joller, AC Anderson, VK Kuchroo - Immunity, 2024 - cell.com
Summary LAG-3, TIM-3, and TIGIT comprise the next generation of immune checkpoint
receptors being harnessed in the clinic. Although initially studied for their roles in restraining …

Beyond T cell exhaustion: TIM-3 regulation of myeloid cells

KO Dixon, GF Lahore, VK Kuchroo - Science immunology, 2024 - science.org
T cell immunoglobulin and mucin domain-containing protein 3 (TIM-3) is an important
immune checkpoint molecule initially identified as a marker of IFN-γ–producing CD4+ and …

The international consensus classification of mature lymphoid neoplasms: a report from the clinical advisory committee

E Campo, ES Jaffe, JR Cook… - Blood, The Journal …, 2022 - ashpublications.org
Since the publication of the Revised European-American Classification of Lymphoid
Neoplasms in 1994, subsequent updates of the classification of lymphoid neoplasms have …

TIM-3 restrains anti-tumour immunity by regulating inflammasome activation

KO Dixon, M Tabaka, MA Schramm, S ** review unveils clinical and diagnostic patterns of a lymphoma subgroup with poor …
J Knauft, T Schenk, T Ernst, U Schnetzke, A Hochhaus… - Leukemia, 2024 - nature.com
Hemophagocytic lymphohistiocytosis (HLH) is a severe hyperinflammatory syndrome driven
by pathologic activation of cytotoxic T-lymphocytes and macrophages. Despite advances in …