Electrical activity in neurons requires a seamless functional coupling between
plasmalemmal ion channels and ion transporters. Although ion channels have been studied …

GABA is the major inhibitory neurotransmitter that counterbalances excitation in the mature
brain. The inhibitory action of GABA relies on the inflow of chloride ions (Cl−), which …

Develo** networks follow common rules to shift from silent cells to coactive networks that
operate via thousands of synapses. This review deals with some of these rules and in …

Recent years have witnessed a steep increase in studies on the diverse roles of neuronal
cation-chloride cotransporters (CCCs). The versatility of CCC gene transcription …

In the nervous system, the intracellular chloride concentration ([Cl−] i) determines the
strength and polarity of γ-aminobutyric acid (GABA)-mediated neurotransmission.[Cl−] i is …

During brain development, transmitter-gated receptors are operative before synapse
formation, suggesting that their action is not restricted to synaptic transmission. GABA, which …

The molecular mechanisms controlling the termination of cortical interneuron migration are
unknown. Here, we demonstrate that, prior to synaptogenesis, migrating interneurons …

GABAergic signalling has the unique property of 'ionic plasticity', which is based on short‐
term and long‐term changes in the Cl− and HCO3− ion concentrations in the postsynaptic …

GABA A receptors mediate fast synaptic inhibition in the CNS. Whilst this is undoubtedly
true, it is a gross oversimplification of their actions. The receptors themselves are diverse …

The type of vesicular transporter expressed by a neuron is thought to determine its
neurotransmitter phenotype. We show that inactivation of the vesicular inhibitory amino acid …