HT receptors expressed throughout the human body are targets for established therapeutics
and various drugs in development. Their diversity of structure and function reflects the …

Serotonin, also known as 5-hydroxytryptamine (5-HT), is a metabolite of tryptophan and is
reported to modulate the development and neurogenesis of the enteric nervous system, gut …

Abstract Serotonin (5-HT) has been recognized for decades as an important signalling
molecule in the gut, but it is still revealing its secrets. Novel gastrointestinal functions of 5-HT …

Although the gastrointestinal (GI) tract possesses intrinsic neural plexuses that allow a
significant degree of autonomy over GI functions, the central nervous system (CNS) provides …

Objectives 5-HT storing enterochromaffin (EC) cells are believed to respond to nutrient and
gut microbial components, and 5-HT receptor-expressing afferent vagal neurons have been …

Abstract Serotonin (5-hydroxytryptamine or 5-HT) is a multifunctional bioamine with
important signaling roles in a range of physiological pathways. Almost all of the 5-HT in our …

The CNS regulates body weight; however, we still lack a clear understanding of what drives
decisions about when, how much and what to eat. A vast array of peripheral signals …

The gut is the only organ that can display reflexes and integrative neuronal activity even
when isolated from the central nervous system. This activity can be triggered by luminal …

Obesity currently represents a major societal and health challenge worldwide. Its prevalence
has reached epidemic proportions and trends continue to rise, reflecting the need for more …

Taste-signaling molecules expressed in the gastrointestinal mucosa might participate in the
functional detection of nutrients and harmful substances in the lumen and prepare the gut to …