One of the most explored therapeutic approaches aimed at eradicating HIV-1 reservoirs is
the “shock and kill” strategy which is based on HIV-1 reactivation in latently-infected cells …

The implementation of antiretroviral therapy 23 years ago has rendered HIV infection
clinically manageable. However, the disease remains incurable, since it establishes latent …

Histone post-translational modifications (HPTMs), as one of the core mechanisms of
epigenetic regulation, are garnering increasing attention due to their close association with …

The DNA sensor cGMP-AMP synthase (cGAS) senses cytosolic microbial or self DNA to
initiate a MITA/STING-dependent innate immune response. cGAS is regulated by various …

Histone posttranslational modifications (HPTMs) are crucial epigenetic mechanisms
regulating various biological events. Different types of HPTMs characterize and shape …

Although HIV-1 replication can be efficiently suppressed to undetectable levels in peripheral
blood by combination antiretroviral therapy (cART), lifelong medication is still required in …

Antiretroviral therapy reduces circulating HIV-1 to undetectable amounts but does not
eliminate the virus due to the persistence of a stable reservoir of latently infected cells. The …

Despite the introduction of combinatory antiretroviral therapy (cART), HIV-1 infection cannot
be cured and is still one of the major health issues worldwide. Indeed, as soon as cART is …

HIV integrates its provirus into the host genome and establishes latent infection.
Antiretroviral therapy (ART) can control HIV viremia, but cannot eradicate or cure the virus …

Transcriptional silencing of latent HIV-1 proviruses entails complex and overlap**
mechanisms that pose a major barrier to in vivo elimination of HIV-1. We developed a new …